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- Hausmann, J.; Hallensleben, W.; De La Torre, J.C.; Pagenstecher, A.; Zimmermann, C.; Pircher, H.; Staeheli, P.
- Proceedings of the National Academy of Sciences of the United States of America 1999 v.96 no.17 pp. 9769-9774
- immune response, etc ; viruses; mice; Borna disease virus; nucleoproteins; immunopathology; brain; immunization; nervous system diseases; encephalitis; cytotoxic T-lymphocytes; CD8-positive T-lymphocytes; CD4-positive T-lymphocytes; Show all 13 Subjects
- ... Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in beta(2)-microglobulin-deficient mice of strain MRL (H-2(k)). Temporary in vivo depletion of CD8(+) T cells delayed BDV-induced disease for several weeks. Depletion of CD4(+) T cells had a similar beneficial effect, indicating that the BDV-induced neurological di ...
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