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- Phillips, John D.; Bergonia, Hector A.; Reilly, Christopher A.; Franklin, Michael R.; Kushner, James P.
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.12 pp. 5079-5084
- biopsy, etc ; animal models; carbon; catalytic activity; chromatography; hemochromatosis; hepatocytes; humans; iron; isomers; liver; mass spectrometry; mice; null alleles; patients; phenotype; photooxidation; polychlorinated biphenyls; porphyria; solid phase extraction; ultraviolet-visible spectroscopy; Show all 21 Subjects
- ... Porphyria cutanea tarda (PCT), the most common form of porphyria in humans, is due to reduced activity of uroporphyrinogen decarboxylase (URO-D) in the liver. Previous studies have demonstrated that protein levels of URO-D do not change when catalytic activity is reduced, suggesting that an inhibitor of URO-D is generated in hepatocytes. Here, we describe the identification and characterization of ...
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