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- Esteban, Alexandre; Popp, Maximilian W.; Vyas, Valmik K.; Strijbis, Karin; Ploegh, Hidde L.; Fink, Gerald R.
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.34 pp. 14270-14275
- immune response, etc ; Candida albicans; beta-glucans; fungi; leukocytes; macrophages; transmembrane proteins; tumor necrosis factor-alpha; Show all 8 Subjects
- ... Dectin-1, the major Î²-glucan receptor in leukocytes, triggers an effective immune response upon fungal recognition. Here we use sortase-mediated transpeptidation, a technique that allows placement of a variety of probes on a polypeptide backbone, to monitor the behavior of labeled functional dectin-1 in live cells with and without fungal challenge. Installation of probes on dectin-1 by sortagging ...
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