Jump to Main Content
- Ge, Jianning; Xu, Hao; Li, Ting; Zhou, Yan; Zhang, Zhibin; Li, Shan; Liu, Liping; Shao, Feng
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.33 pp. 13725-13730
- immune response, etc ; IKappaB kinase; Legionella pneumophila; Legionnaires' disease; gene expression regulation; genes; inflammation; macrophages; mitogen-activated protein kinase; pathogens; phosphorylation; pneumonia; transcription factor NF-kappa B; type IV secretion system; Show all 14 Subjects
- ... NF-κB is critical in innate immune defense responses against invading microbial pathogens. Legionella pneumophila infection of lung macrophages causes Legionnaire's disease with pneumonia symptoms. A set of NF-κB-controlled genes involved in inflammation and anti-apoptosis are up-regulated in macrophages upon L. pneumophila infection in a Legionella Dot/Icm type IV secretion system-dependent manne ...
- PubMed Central: