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- Amos-Landgraf, James M.; Kwong, Lawrence N.; Kendziorski, Christina M.; Reichelderfer, Mark; Torrealba, Jose; Weichert, Jamey; Haag, Jill D.; Chen, Kai-Shun; Waller, Jordy L.; Gould, Michael N.; Dove, William F.
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.10 pp. 4036-4041
- chromosome elimination, etc ; alleles; animal models; chemoprevention; colon; colorectal neoplasms; computed tomography; endoscopy; genetic background; genotype-phenotype correlation; humans; karyotyping; longitudinal studies; mice; mutants; patients; phenotype; rats; small intestine; Show all 19 Subjects
- ... Progress toward the understanding and management of human colon cancer can be significantly advanced if appropriate experimental platforms become available. We have investigated whether a rat model carrying a knockout allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer of the human more closely than existing murine models. We have established a mutage ...
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- Yoon, H.J.; Carbon, J.
- Proceedings of the National Academy of Sciences of the United States of America 1999 v.96 no.23 pp. 13208-13213
- chromosome elimination, etc ; Saccharomyces cerevisiae; chromosome segregation; proteins; apoptosis; metabolic inhibitors; binding proteins; chromatin; mutants; centromeres; gene dosage; gene expression; genes; phenotype; gene overexpression; Show all 15 Subjects
- ... Yeast two-hybrid and genetic interaction screens indicate that Bir1p, a yeast protein containing phylogenetically conserved antiapoptotic repeat domains called baculovirus inhibitor of apoptosis repeats (BIRs), is involved in chromosome segregation events. In the two-hybrid screen, Bir1p specifically interacts with Ndc10p, an essential component of the yeast kinetochore. Although Bir1p carries two ...
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