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- Ren, Ruibao, et al. Show all 11 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.6 pp. 2450-2455
- gene fusion; humans; hybrids; longevity; lymphocytic leukemia; mice; models; mutants; mutation; myeloid leukemia; pathogenesis; patients; synergism; transcription factors; tyrosine
- ... The full-length AML1-ETO (AE) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in animals, suggesting that additional mutations are required for leukemogenesis. We and others have identified activating mutations of C-KIT in nearly half of patients with t(8;21) AML. To test the hypothesis that activating C-KIT mutations cooperate ...
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