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You searched for: Author "Sharma, Cynthia M." Remove constraint Author: "Sharma, Cynthia M." Journal Proceedings of the National Academy of Sciences of the United States of America Remove constraint Journal: Proceedings of the National Academy of Sciences of the United States of America
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1. Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation

Author:
Sharma, Cynthia M.,   et al.   ; Papenfort, Kai; Förstner, Konrad U.; Cong, Jian-Ping; Bassler, Bonnie L.;     Show all 5 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.7 pp. E766
ISSN:
0027-8424
Subject:
Vibrio cholerae; biofilm; group behavior; humans; messenger RNA; pathogens; transcription (genetics); transcription factors
Abstract:
... Quorum sensing (QS) is a process of cell-to-cell communication that enables bacteria to transition between individual and collective lifestyles. QS controls virulence and biofilm formation in Vibrio cholerae , the causative agent of cholera disease. Differential RNA sequencing (RNA-seq) of wild-type V. cholerae and a locked low-cell-density QS-mutant strain identified 7,240 transcriptional start s ...
DOI:
10.1073/pnas.1500203112
PubMed:
25646441
PubMed Central:
PMC4343088

2. A variable homopolymeric G-repeat defines small RNA-mediated posttranscriptional regulation of a chemotaxis receptor in Helicobacter pylori

Author:
Sharma, Cynthia M.,   et al.   ; Pernitzsch, Sandy R.; Tirier, Stephan M.; Beier, Dagmar;     Show all 4 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.4 pp. E501
ISSN:
0027-8424
Subject:
Helicobacter pylori; chemotaxis; gene expression; genes; humans; messenger RNA; microsatellite repeats; mutation; pathogens; phenotypic variation; translation (genetics); virulence
Abstract:
... Phase variation of hypermutable simple sequence repeats (SSRs) is a widespread and stochastic mechanism to generate phenotypic variation within a population and thereby contributes to host adaptation of bacterial pathogens. Although several examples of SSRs that affect transcription or coding potential have been reported, we now show that a SSR also impacts small RNA-mediated posttranscriptional r ...
DOI:
10.1073/pnas.1315152111
PubMed:
24474799
PubMed Central:
PMC3910625

3. Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA

Author:
Sharma, Cynthia M.,   et al.   ; Papenfort, Kai; Bouvier, Marie; Mika, Franziska; Vogel, Jörg;     Show all 5 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.47 pp. 20435-20440
ISSN:
0027-8424
Subject:
Salmonella; adenosine; animals; homeostasis; messenger RNA; microRNA; outer membrane proteins; regulon; translation (genetics)
Abstract:
... The abundant class of bacterial Hfq-associated small regulatory RNAs (sRNAs) parallels animal microRNAs in their ability to control multiple genes at the posttranscriptional level by short and imperfect base pairing. In contrast to the universal length and seed pairing mechanism of microRNAs, the sRNAs are heterogeneous in size and structure, and how they regulate multiple targets is not well unde ...
DOI:
10.1073/pnas.1009784107
PubMed:
21059903
PubMed Central:
PMC2996696

4. Deep sequencing analysis of the Methanosarcina mazei Gö1 transcriptome in response to nitrogen availability

Author:
Sharma, Cynthia M.,   et al.   ; Jäger, Dominik; Thomsen, Jens; Ehlers, Claudia; Vogel, Jörg; Schmitz, Ruth A.;     Show all 6 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.51 pp. 21878-21882
ISSN:
0027-8424
Subject:
5' untranslated regions; Methanosarcina mazei; acetates; binding sites; carbon dioxide; gene expression regulation; genes; greenhouse gases; high-throughput nucleotide sequencing; intergenic DNA; methane; methanol; nitrogen; open reading frames; promoter regions; transcription (genetics); transcriptome; transposition (genetics)
Abstract:
... Methanosarcina mazei and related mesophilic archaea are the only organisms fermenting acetate, methylamines, and methanol to methane and carbon dioxide, contributing significantly to greenhouse gas production. The biochemistry of these metabolic processes is well studied, and genome sequences are available, yet little is known about the overall transcriptional organization and the noncoding region ...
DOI:
10.1073/pnas.0909051106
PubMed:
19996181
PubMed Central:
PMC2799843

5. An experimentally anchored map of transcriptional start sites in the model cyanobacterium Synechocystis sp. PCC6803

Author:
Sharma, Cynthia M.,   et al.   ; Mitschke, Jan; Georg, Jens; Scholz, Ingeborg; Dienst, Dennis; Bantscheff, Jens; Voss, Björn; Steglich, Claudia; Wilde, Annegret; Vogel, Jörg; Hess, Wolfgang R.;     Show all 11 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.5 pp. 2124-2129
ISSN:
0027-8424
Subject:
Synechocystis; autotrophs; bioengineering; biofuels; energy; genes; intergenic DNA; messenger RNA; microarray technology; non-coding RNA; photosynthesis; solar energy; transcription (genetics)
Abstract:
... There has been an increasing interest in cyanobacteria because these photosynthetic organisms convert solar energy into biomass and because of their potential for the production of biofuels. However, the exploitation of cyanobacteria for bioengineering requires knowledge of their transcriptional organization. Using differential RNA sequencing, we have established a genome-wide map of 3,527 transcr ...
DOI:
10.1073/pnas.1015154108
PubMed:
21245330
PubMed Central:
PMC3033270