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- Urbanc, Brigita, et al. Show all 12 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.37 pp. 14175-14180
- Alzheimer disease; cell death; cell viability; computer simulation; drugs; neurons; neurotoxicity; oligomerization; peptides; therapeutics
- ... Alzheimer's disease (AD) is an age-related disorder that threatens to become an epidemic as the world population ages. Neurotoxic oligomers of Aβ42 are believed to be the main cause of AD; therefore, disruption of Aβ oligomerization is a promising approach for developing therapeutics for AD. Formation of Aβ42 oligomers is mediated by intermolecular interactions in which the C terminus plays a cent ...
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