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- Hamdar, Alaa; El Hage, Salomé; El Garah, Fatima; Baziard, Geneviève; Roques, Christine; Lajoie, Barbora
- Process biochemistry 2019 v.77 pp. 18-22
- NAD(P)H oxidase (H2O2-forming); Saccharothrix; butanol; culture media; elicitors; enzyme inhibitors; ethanol
- ... The production of dithiolopyrrolones by Saccharothrix algeriensis was investigated after supplementing the culture medium with ethanol and/or 1-butanol. Optimal conditions for the addition of ethanol to the culture medium provided a maximal dithiolopyrrolone titer of about 200 mg⋅L−1 after 5 days of culture, roughly corresponding to a 600%-increase. Using NAD(P)H oxidase inhibitor (diphenyleneiodo ...