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- Bret Cooper
- Proteomics 2016 v.16 no.18 pp. 2444-2447
- algorithms; databases; information retrieval; peptides; phosphorylation; proteomics; serine; threonine
- ... Some mass spectrometrists believe that searching for variable PTMs like phosphorylation of serine or threonine when using database-search algorithms to interpret peptide tandem mass spectra will increase false-positivematching. The basis for this is the premise that the algorithm compares a spectrum to both a nonphosphorylated peptide candidate and a phosphorylated candidate, which is double the n ...