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- Dou, Tongyi, et al. Show all 5 Authors
- RSC advances 2018 v.8 no.29 pp. 16278-16284
- New Zealand White rabbit; animal models; catechol O-methyltransferase; dogs; fluorescent dyes; guinea pigs; humans; laboratory animals; liver; metabolites; methylation; mice; miniature swine; monkeys; peripheral nervous system diseases; rats; therapeutics
- ... Catechol-O-methyltransferase (COMT) is a druggable biological target and COMT modulators have been widely applied in the treatment of various central and peripheral nervous system disorders. The interspecies differences of COMT were carefully investigated using 3-BTD (a newly developed fluorescent probe of COMT) methylation as the probe reaction, and liver S9 from humans and seven experimental ani ...