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- Ruchirawat, Somsak, et al. Show all 4 Authors
- RSC advances 2016 v.6 no.54 pp. 48666-48675
- chlorine; hydrochloric acid; oximes; solvents
- ... For the first time, 4-chloroisoxazoles are directly synthesized in moderate to excellent yields from (E/Z)-alkynyl-O-methyl oximes via chlorinative cyclization. The synthesis employs the combination of N-chlorosuccinimide (NCS) and chlorotrimethylsilane (TMSCl) in nitromethane solvent where chlorine (Cl₂) and hydrochloric acid (HCl) are generated in situ. In addition, the current protocol is appli ...