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- Liao, Mengqin, et al. Show all 7 Authors
- Reproduction, fertility, and development 2019 v.31 no.3 pp. 473-481
- DNA damage; DNA repair; X-radiation; blastocyst; breast neoplasms; embryogenesis; etoposide; extrusion; fluorescent antibody technique; genes; germinal vesicle; meiosis; messenger RNA; protein kinases; protein subunits; recombinant DNA; swine; tumor suppressor proteins
- ... Faithful repair of DNA double-strand breaks in mammalian oocytes is essential for meiotic maturation and embryonic development. In the present study we investigated the roles of Roscovitine and Trichostatin A (TSA) in DNA damage recovery during invitro maturation of porcine oocytes. Etoposide was used to trigger DNA damage in oocytes. When these DNA-damaged oocytes were treated with 2μM Roscovitin ...