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- Priego-Capote, Feliciano, et al. Show all 9 Authors
- Research in veterinary science 2017 v.114 pp. 117-122
- angiotensin-converting enzyme inhibitors; bioavailability; blood pressure; blood sampling; blood serum; cross-over studies; drugs; horses; intravenous injection; liquid chromatography; models; patients; peptidyl-dipeptidase A; pharmacodynamics; pharmacokinetics; placebos; tandem mass spectrometry
- ... Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV) and oral (PO) administration of benazepril using a PK/PD model. This study also aims to determine the effects of benazeprilat on serum angi ...