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- Lutz, Susanne; Shankaranarayanan, Aruna; Coco, Cassandra; Ridilla, Marc; Nance, Mark R.; Vettel, Christiane; Baltus, Doris; Evelyn, Chris R.; Neubig, Richard R.; Wieland, Thomas; Tesmer, John J.G.
- Science 2007 v.318 no.5858 pp. 1923-1927
- G-protein coupled receptors, etc ; G-proteins; crystal structure; guanine nucleotide exchange factors; pleckstrin; signal transduction; Show all 6 Subjects
- ... The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide-binding protein (G protein) Gαq and thereby links Gαq-coupled receptors (GPCRs) to the activation of the small-molecular-weight G protein RhoA. We determined the crystal structure of the Gαq-p63RhoGEF-RhoA complex, detailing the interactions of Gαq with the Dbl and pleckstrin homology (DH and P ...