PubAg

Main content area

You searched for: Journal Science Remove constraint Journal: Science Publication Year 2005 Remove constraint Publication Year: 2005 Source 2005 v.307 no.5707 Remove constraint Source: 2005 v.307 no.5707
Start Over

Search

17  Search Results

1 - 17 of 17
Number of results to display per page

Search Results

1. A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

Author:
Andries, Koen; Verhasselt, Peter; Guillemont, Jerome; Göhlmann, Hinrich W. H.; Neefs, Jean-Marc; Winkler, Hans; Van Gestel, Jef; Timmerman, Philip; Zhu, Min; Lee, Ennis; Williams, Peter; de Chaffoy, Didier; Huitric, Emma; Hoffner, Sven; Cambau, Emmanuelle; Truffot-Pernot, Chantal; Lounis, Nacer; Jarlier, Vincent
Source:
Science 2005 v.307 no.5707 pp. 223-227
ISSN:
0036-8075
Subject:
H+/K+-exchanging ATPase; H-transporting ATP synthase; Mycobacterium tuberculosis; World Health Organization; antibacterial properties; drug resistance; drugs; humans; isoniazid; mice; minimum inhibitory concentration; mutants; proton pump; rifampicin; tuberculosis; volunteers
Abstract:
... The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We identified a diarylquinoline, R207910, that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro (minimum inhibitory concentration 0.06 [micro]g/ml). In mice, R207910 exceeded the b ...
DOI:
10.1126/science.1106753

2. Al Cluster Superatoms as Halogens in Polyhalides and as Alkaline Earths in Iodide Salts

Author:
Bergeron, D. E.; Roach, P. J.; Castleman, A. W.; Jones, N. O.; Khanna, S. N.
Source:
Science 2005 v.307 no.5707 pp. 231-235
ISSN:
0036-8075
Subject:
aluminum; gases; halogens; iodides; models
Abstract:
... Two classes of gas-phase aluminum-iodine clusters have been identified whose stability and reactivity can be understood in terms of the spherical shell jellium model. Experimental reactivity studies show that the Al₁₃I ⁻[subscript x] clusters exhibit pronounced stability for even numbers of I atoms. Theoretical investigations reveal that the enhanced stability is associated with complementary pair ...
DOI:
10.1126/science.1105820

3. An Astronomical 2175 Å Feature in Interplanetary Dust Particles

Author:
Bradley, John; Dai, Zu Rong; Erni, Rolf; Browning, Nigel; Graham, Giles; Weber, Peter; Smith, Julie; Hutcheon, Ian; Ishii, Hope; Bajt, Sasa; Floss, Christine; Stadermann, Frank; Sandford, Scott
Source:
Science 2005 v.307 no.5707 pp. 244-247
ISSN:
0036-8075
Subject:
carbon; dust; extinction; silicates; transmission electron microscopes; wavelengths
Abstract:
... The 2175 angstrom extinction feature is the strongest (visible-ultraviolet) spectral signature of dust in the interstellar medium. Forty years after its discovery, the origin of the feature and the nature of the carrier(s) remain controversial. Using a transmission electron microscope, we detected a 5.7-electron volt (2175 angstrom) feature in interstellar grains embedded within interplanetary dus ...
DOI:
10.1126/science.1106717

4. Anticonvulsant Medications Extend Worm Life-Span

Author:
Evason, Kimberley; Huang, Cheng; Yamben, Idella; Covey, Douglas F.; Kornfeld, Kerry
Source:
Science 2005 v.307 no.5707 pp. 258-262
ISSN:
0036-8075
Subject:
Caenorhabditis elegans; anticonvulsants; humans
Abstract:
... Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. T ...
DOI:
10.1126/science.1105299

5. A Stable Aminyl Radical Metal Complex

Author:
Bůttner, Torsten; Geier, Jens; Frison, Gilles; Harmer, Jeffrey; Calle, Carlos; Schweiger, Arthur; Schönberg, Hartmut; Grůtzmacher, Hansjörg
Source:
Science 2005 v.307 no.5707 pp. 235-238
ISSN:
0036-8075
Subject:
electron paramagnetic resonance spectroscopy; free radicals; oxidation
Abstract:
... Metal-stabilized phenoxyl radicals appear to be important intermediates in a variety of enzymatic oxidations. We report that transition metal coordination also supports an aminyl radical, resulting in a stable crystalline complex: [Rh(I)(trop₂N[superscript .])(bipy)]⁺OTf⁻ (where trop is 5-H-dibenzo[a,d]cycloheptene-5-yl, bipy is 2,2'-bipyridyl, OTf⁻ is trifluorosulfonate). It is accessible under m ...
DOI:
10.1126/science.1106070

6. Corrected Late Triassic Latitudes for Continents Adjacent to the North Atlantic

Author:
Kent, Dennis V.; Tauxe, Lisa
Source:
Science 2005 v.307 no.5707 pp. 240-244
ISSN:
0036-8075
Subject:
basins; geophysics; igneous rocks; latitude; magnetic fields; models; sedimentary rocks; Europe; Greenland; North America
Abstract:
... We use a method based on a statistical geomagnetic field model to recognize and correct for inclination error in sedimentary rocks from early Mesozoic rift basins in North America, Greenland, and Europe. The congruence of the corrected sedimentary results and independent data from igneous rocks on a regional scale indicates that a geocentric axial dipole field operated in the Late Triassic. The co ...
DOI:
10.1126/science.1105826

7. CX₃CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Author:
Niess, Jan Hendrik; Brand, Stephan; Gu, Xiubin; Landsman, Limor; Jung, Steffen; McCormick, Beth A.; Vyas, Jatin M.; Boes, Marianne; Ploegh, Hidde L.; Fox, James G.; Littman, Dan R.; Reinecker, Hans-Christian
Source:
Science 2005 v.307 no.5707 pp. 254-258
ISSN:
0036-8075
Subject:
adaptive immunity; antigens; bacteria; chemokine receptors; dendrites; dendritic cells; inflammation; macrophages; mice; pathogens; small intestine
Abstract:
... Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX₃CR1 to form transepithelial dendrites, which enable the cells to directly sample lumin ...
DOI:
10.1126/science.1102901

8. Encapsulation of Molecular Hydrogen in Fullerene C₆₀ by Organic Synthesis

Author:
Komatsu, Koichi; Murata, Michihisa; Murata, Yasujiro
Source:
Science 2005 v.307 no.5707 pp. 238-240
ISSN:
0036-8075
Subject:
chemical reactions; encapsulation; fullerene; hydrogen; surgery; synthesis
Abstract:
... In spite of their importance in fundamental and applied studies, the preparation of endohedral fullerenes has relied on difficult-to-control physical methods. We report a four-step organic reaction that completely closes a 13-membered ring orifice of an open-cage fullerene. This process can be used to synthesize a fullerene C₆₀ encapsulating molecular hydrogen, which can be isolated as a pure prod ...
DOI:
10.1126/science.1106185

9. Global Circumnavigations: Tracking Year-Round Ranges of Nonbreeding Albatrosses

Author:
Croxall, John P.; Silk, Janet R. D.; Phillips, Richard A.; Afanasyev, Vsevolod; Briggs, Dirk R.
Source:
Science 2005 v.307 no.5707 pp. 249-250
ISSN:
0036-8075
Subject:
adults; birds; breeding; fisheries; foraging; habitats; home range; Indian Ocean
Abstract:
... Although albatrosses are paradigms of oceanic specialization, their foraging areas and migration routes when not breeding remain essentially unknown. Our continuous remote tracking of 22 adult gray-headed albatrosses for over 30 bird-years reveals three distinct strategies: (i) Stay in breeding home range; (ii) make return migrations to a specific area of the southwest Indian Ocean; and (iii) make ...
DOI:
10.1126/science.1106042

10. No Transcription-Translation Feedback in Circadian Rhythm of KaiC Phosphorylation

Author:
Tomita, Jun; Nakajima, Masato; Kondo, Takao; Iwasaki, Hideo
Source:
Science 2005 v.307 no.5707 pp. 251-254
ISSN:
0036-8075
Subject:
Synechococcus elongatus; circadian rhythm; messenger RNA; models; phosphorylation; temperature; transcription (genetics); translation (genetics)
Abstract:
... An autoregulatory transcription-translation feedback loop is thought to be essential in generating circadian rhythms in any model organism. In the cyanobacterium Synechococcus elongatus, the essential clock protein KaiC is proposed to form this type of transcriptional negative feedback. Nevertheless, we demonstrate here temperature-compensated, robust circadian cycling of KaiC phosphorylation even ...
DOI:
10.1126/science.1102540

11. Retinoic Acid Signaling Restricts the Cardiac Progenitor Pool

Author:
Keegan, Brian R.; Feldman, Jessica L.; Begemann, Gerrit; Ingham, Philip W.; Yelon, Deborah
Source:
Science 2005 v.307 no.5707 pp. 247-249
ISSN:
0036-8075
Subject:
Danio rerio; cardiomyocytes; organogenesis; retinoic acid; stem cells
Abstract:
... Organogenesis begins with specification of a progenitor cell population, the size of which provides a foundation for the organ's final dimensions. Here, we present a new mechanism for regulating the number of progenitor cells by limiting their density within a competent region. We demonstrate that retinoic acid signaling restricts cardiac specification in the zebrafish embryo. Reduction of retinoi ...
DOI:
10.1126/science.1101573

12. Self-Propagating, Molecular-Level Polymorphism in Alzheimer's [beta]-Amyloid Fibrils

Author:
Petkova, Aneta T.; Leapman, Richard D.; Guo, Zhihong; Yau, Wai-Ming; Mattson, Mark P.; Tycko, Robert
Source:
Science 2005 v.307 no.5707 pp. 262-265
ISSN:
0036-8075
Subject:
Alzheimer disease; amyloid; cell culture; chemical structure; electron microscopy; nanomaterials; neurons; nuclear magnetic resonance spectroscopy; prion diseases
Abstract:
... Amyloid fibrils commonly exhibit multiple distinct morphologies in electron microscope and atomic force microscope images, often within a single image field. By using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue [beta]-amyloid peptide of Alzheimer's disease (A[beta]₁₋₄₀), we show that different fibril morphologies have different un ...
DOI:
10.1126/science.1105850

13. Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins

Author:
Gu, Chenghua; Yoshida, Yutaka; Livet, Jean; Reimert, Dorothy V.; Mann, Fanny; Merte, Janna; Henderson, Christopher E.; Jessell, Thomas M.; Kolodkin, Alex L.; Ginty, David D.
Source:
Science 2005 v.307 no.5707 pp. 265-268
ISSN:
0036-8075
Subject:
endothelial cells; mice; organogenesis; signal transduction
Abstract:
... The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent in ...
DOI:
10.1126/science.1105416

14. Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

Author:
Yuan, Zheng-long; Guan, Ying-jie; Chatterjee, Devasis; Chin, Y. Eugene
Source:
Science 2005 v.307 no.5707 pp. 269-273
ISSN:
0036-8075
Subject:
DNA; acetylation; cell cycle; cytokines; dimerization; genes; histone acetyltransferase; histone deacetylase; lysine; mutants; prostatic neoplasms; proteins; serine; signal transduction; transcription (genetics); tyrosine
Abstract:
... Upon cytokine treatment, members of the signal transducers and activators of transcription (STAT) family of proteins are phosphorylated on tyrosine and serine sites within the carboxyl-terminal region in cells. We show that in response to cytokine treatment, Stat3 is also acetylated on a single lysine residue, Lys⁶⁸⁵. Histone acetyltransferase p300-mediated Stat3 acetylation on Lys⁶⁸⁵ was reversib ...
DOI:
10.1126/science.1105166

15. Testing Hypotheses: Prediction and Prejudice

Author:
Lipton, Peter
Source:
Science 2005 v.307 no.5707 pp. 219-221
ISSN:
0036-8075
Subject:
prediction; risk; testing
Abstract:
... Observations that fit a hypothesis may be made before or after the hypothesis is formulated. Can that difference be relevant to the amount of support that the observations provide for the hypothesis? Philosophers of science and statisticians are both divided on this question, but there is an argument that predictions ought to count more than accommodations, because of the risk of "fudging" that ac ...
DOI:
10.1126/science.1103024

16. The First Glacial Maximum in North America

Author:
Balco, Greg; Rovey, Charles W.; Stone, John O. H.
Source:
Science 2005 v.307 no.5707 pp. 222
ISSN:
0036-8075
Subject:
glacial deposits; ice; nuclides; paleosolic soil types; North America
Abstract:
... Despite marine evidence for at least 50 Pliocene-Pleistocene ice sheet advances, only the most recent one has been accurately reconstructed from terrestrial evidence, because there are few techniques for dating older glacial deposits. Here we show that the cosmic ray-produced nuclides beryllium-10 and aluminum-26 can be used to date tills that overlie paleosols. ...
DOI:
10.1126/science.1103406

17. Time-Domain Measurements of Nanomagnet Dynamics Driven by Spin-Transfer Torques

Author:
Krivorotov, I. N.; Emley, N. C.; Sankey, J. C.; Kiselev, S. I.; Ralph, D. C.; Buhrman, R. A.
Source:
Science 2005 v.307 no.5707 pp. 228-231
ISSN:
0036-8075
Subject:
magnetic fields; nanotechnology; torque
Abstract:
... We present time-resolved measurements of gigahertz-scale magnetic dynamics caused by torque from a spin-polarized current. By working in the time domain, we determined the motion of the magnetic moment throughout the process of spin-transfer-driven switching, and we measured turn-on times of steady-state precessional modes. Time-resolved studies of magnetic relaxation allow for the direct measurem ...
DOI:
10.1126/science.1105722