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- Opferman, Joseph T.; Iwasaki, Hiromi; Ong, Christy C.; Suh, Heikyung; Mizuno, Shin-ichi; Akashi, Koichi; Korsmeyer, Stanley J.
- Science 2005 v.307 no.5712 pp. 1101-1104
- apoptosis; bone marrow; genes; hematopoietic stem cells; homeostasis; liver; mice; stem cell factor; transcription (genetics)
- ... Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not precisely defined. We tested myeloid leukemia-1 (MCL-1) as an attractive candidate that is highly expressed in HSCs and regulated by growth factor signals. Inducible deletion of Mcl-1 in mice resulted in ablation of bone marrow. This result ...