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You searched for: Journal name Science Remove constraint Journal name: Science Source 2011 v.331 no.6017 Remove constraint Source: 2011 v.331 no.6017 Subject term humans Remove constraint Subject term: humans
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1. 2500 Years of European Climate Variability and Human Susceptibility

Author:
Büntgen, Ulf; Tegel, Willy; Nicolussi, Kurt; McCormick, Michael; Frank, David; Trouet, Valerie; Kaplan, Jed O.; Herzig, Franz; Heussner, Karl-Uwe; Wanner, Heinz; Luterbacher, Jürg; Esper, Jan
Source:
Science 2011 v.331 no.6017 pp. 578-582
ISSN:
0036-8075
Subject:
anthropogenic activities; climate; climate change; humans; politics; risk; summer; temperature
Abstract:
... Climate variations influenced the agricultural productivity, health risk, and conflict level of preindustrial societies. Discrimination between environmental and anthropogenic impacts on past civilizations, however, remains difficult because of the paucity of high-resolution paleoclimatic evidence. We present tree ring-based reconstructions of central European summer precipitation and temperature ...
DOI:
10.1126/science.1197175

2. A Cryptic Subgroup of Anopheles gambiae Is Highly Susceptible to Human Malaria Parasites

Author:
Riehle, Michelle M.; Guelbeogo, Wamdaogo M.; Gneme, Awa; Eiglmeier, Karin; Holm, Inge; Bischoff, Emmanuel; Garnier, Thierry; Snyder, Gregory M.; Li, Xuanzhong; Markianos, Kyriacos; Sagnon, N'Fale; Vernick, Kenneth D.
Source:
Science 2011 v.331 no.6017 pp. 596-598
ISSN:
0036-8075
Subject:
Anopheles gambiae; Plasmodium falciparum; adults; biological resistance; habitats; humans; insect vectors; larvae; malaria; oviposition sites; parasites; savannas; surveys; sympatry; Western Africa
Abstract:
... Population subgroups of the African malaria vector Anopheles gambiae have not been comprehensively characterized owing to the lack of unbiased sampling methods. In the arid savanna zone of West Africa, where potential oviposition sites are scarce, widespread collection from larval pools in the peridomestic human habitat yielded a comprehensive genetic survey of local A. gambiae population subgroup ...
DOI:
10.1126/science.1196759
PubMed:
21292978
PubMed Central:
PMC3065189

3. Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

Author:
Ting, David T.; Lipson, Doron; Paul, Suchismita; Brannigan, Brian W.; Akhavanfard, Sara; Coffman, Erik J.; Contino, Gianmarco; Deshpande, Vikram; Iafrate, A. John; Letovsky, Stan; Rivera, Miguel N.; Bardeesy, Nabeel; Maheswaran, Shyamala; Haber, Daniel A.
Source:
Science 2011 v.331 no.6017 pp. 593-596
ISSN:
0036-8075
Subject:
adenocarcinoma; animal ovaries; biomarkers; colon; epithelium; gene overexpression; gene silencing; genes; heterochromatin; humans; kidneys; mice; microsatellite repeats; non-coding RNA; plant ovary; retrotransposons; satellites; transcription (genetics)
Abstract:
... Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been linked to gene silencing and maintenance of chromosomal integrity. Using digital gene expression analysis, we showed that these transcripts are greatly overexpressed in mouse and human epithelial cancers. In 8 of 10 mouse pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean ...
DOI:
10.1126/science.1200801
PubMed:
21233348
PubMed Central:
PMC3701432