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- Styer, Katie L.; Singh, Varsha; Macosko, Evan; Steele, Sarah E.; Bargmann, Cornelia I.; Aballay, Alejandro
- Science 2008 v.322 no.5900 pp. 460-464
- G-protein coupled receptors, etc ; Caenorhabditis elegans; genes; guanylate cyclase; immune response; innate immunity; ion channels; mammals; microarray technology; mitogen-activated protein kinase; mutation; neural networks; neuropeptide Y; pathogens; sensory neurons; signal transduction; Show all 16 Subjects
- ... A large body of evidence indicates that metazoan innate immunity is regulated by the nervous system, but the mechanisms involved in the process and the biological importance of such control remain unclear. We show that a neural circuit involving npr-1, which encodes a G protein-coupled receptor (GPCR) related to mammalian neuropeptide Y receptors, functions to suppress innate immune responses. The ...
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- Yauch, Robert L.; Dijkgraaf, Gerrit J.P.; Alicke, Bruno; Januario, Thomas; Ahn, Christina P.; Holcomb, Thomas; Pujara, Kanan; Stinson, Jeremy; Callahan, Christopher A.; Tang, Tracy; Bazan, J. Fernando; Kan, Zhengyan; Seshagiri, Somasekar; Hann, Christine L.; Gould, Stephen E.; Low, Jennifer A.; Rudin, Charles M.; de Sauvage, Frederic J.
- Science 2009 v.326 no.5952 pp. 572-574
- G-protein coupled receptors, etc ; amino acid substitution; animal models; aspartic acid; brain; clinical trials; disease course; drug resistance; drugs; genes; humans; neoplasms; patients; serpentine; signal transduction; Show all 15 Subjects
- ... The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that inhibits Hh signaling by targeting the serpentine receptor Smoothened (SMO), has produced promising anti-tumor responses in early clinical studies of cancers driven by mutations in this pathway. To evaluate the mechanism of resistanc ...
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