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- Zeng, Hui, et al. Show all 11 Authors
- Science 2005 v.310 no.5745 pp. 77
- Influenza A virus; molecular genetics; genes; virus replication; trypsin; viral diseases of animals and humans; mortality; mice; eggs; microbial growth; human cell lines; epithelium; bronchi; virulence
- ... The pandemic influenza virus of 1918-1919 killed an estimated 20 to 50 million people worldwide. With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse genetics to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence. In stark contrast to contemporary human i ...