Jump to Main Content
- Miller, Michael W., et al. Show all 7 Authors
- Science 2006 v.311 no.5764 pp. 1117
- Cervidae; bioassays; bovine spongiform encephalopathy; chronic wasting disease; deer; disease transmission; elks; humans; meat; meat consumption; pathogenicity; prions; risk; skeletal muscle; transgenic animals; zoonoses
- ... The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic potential of CWD. Because meat consumption is the most likely means of exposure, it is important to determine whether s ...
- Miller, Michael W., et al. Show all 17 Authors
- Science 2006 v.314 no.5796 pp. 133-136
- Cervidae; blood; chronic wasting disease; deer; feces; prions; saliva; urine
- ... A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-naïve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transf ...