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- Atasoy, Deniz, et al. Show all 6 Authors
- Science 2011 v.333 no.6047 pp. 1292-1296
- animal behavior; chemistry; functional properties; ion channels; mammals; neurons; protein engineering
- ... Ionic flux mediates essential physiological and behavioral functions in defined cell populations. Cell type–specific activators of diverse ionic conductances are needed for probing these effects. We combined chemistry and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacologic selectivity and divergent functional propert ...
- PubMed Central: