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- Mi, Sha, et al. Show all 11 Authors
- Science 2005 v.310 no.5755 pp. 1813-1817
- glycoproteins; mice; myelin sheath; nerve tissue; neurites; oligodendroglia; proteomics; rats; spinal cord
- ... Nodes of Ranvier are regularly placed, nonmyelinated axon segments along myelinated nerves. Here we show that nodal membranes isolated from the central nervous system (CNS) of mammals restricted neurite outgrowth of cultured neurons. Proteomic analysis of these membranes revealed several inhibitors of neurite outgrowth, including the oligodendrocyte myelin glycoprotein (OMgp). In rat spinal cord, ...