Jump to Main Content
- Leonardi, William; Zilbermintz, Leeor; Cheng, Luisa W. W.; Zozaya, Josue; Tran, Sharon H.; Elliott, Jeffrey H.; Polukhina, Kseniya; Manasherob, Robert; Li, Amy; Chi, Xiaoli; Gharaibeh, Dima; Kenny, Tara; Zamani, Rouzbeh; Soloveva, Veronica; Haddow, Andrew D.; Nasar, Farooq; Bavari, Sina; Bassik, Michael C.; Cohen, Stanley N.; Levitin, Anastasia; Martchenko, Mikhail
- Scientific Reports 2016 v.6 no.1
- Africans; Asians; Europeans; Pseudomonas aeruginosa; Zika virus; ancestry; anthrax; anti-infective agents; botulinum toxin; caspases; cholera toxin; drugs; enzyme inhibitors; exotoxins; hosts; pathogenicity; ricin; therapeutics
- ... Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these networks represent attractive targets for broad-spectrum drugs. Using bacterial toxins, we describe a new approach for discovering broad-spectrum therapies capable of inhibiting host proteins that mediate multiple pathogenic pathways. This approach can be widely used, as it combines genetic-based targe ...
- PubMed Central: