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- Beck, Alain, et al. Show all 10 Authors
- Talanta 2018 v.178 pp. 530-537
- biopharmaceuticals; capillary electrophoresis; fluorescence; glycopeptides; glycosylation; hydrophilic interaction chromatography; mass spectrometry; monoclonal antibodies; polysaccharides; protein structure
- ... Characterization of therapeutic proteins represents a major challenge for analytical sciences due to their heterogeneity caused by post-translational modifications (PTM). Among these PTM, glycosylation which is possibly the most prominent, require comprehensive identification because of their major influence on protein structure and effector functions of monoclonal antibodies (mAbs). As a conseque ...