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- Li, Deshan, et al. Show all 9 Authors
- Technology in Cancer Research and Treatment 2014 v.13 no.2 pp. 169-175
- Newcastle disease virus; anticarcinogenic activity; carcinoma; genetically engineered microorganisms; green fluorescent protein; hepatoma; recombinant DNA; therapeutics; viruses
- ... Hepatocellular carcinoma remains one of the most common malignant tumors in the world. Newcastle disease virus (NDV) has been proved to be an efficient oncolytic agent. NDV tumor killing efficacy is not only dependening on the NDV strain but the type of tumor targeted. It is significant to discover more effective and safe oncolytic strains. We investigated the effectiveness of genetically engineer ...
- Li, Deshan, et al. Show all 13 Authors
- Technology in Cancer Research and Treatment 2014 pp. 1-9
- Newcastle disease virus; T-lymphocytes; adverse effects; genes; humans; interferon-gamma; interleukin-2; melanoma; metastasis; mice; models; natural killer cells; survival rate; therapeutics; toxicity; viruses
- ... Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 has shown promise in cancer therapy. Due to the significant side effects of IL2, IL15 has been introduced into cancer therapy. A number of studies have suggested that IL15 efficiently enhances the activities of CTL and NK cells and inhibits the tum ...