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- Sun, Mengli; Su, Lebin; Dong, Jianyu; Liu, Long; Zhou, Yongbo; Yin, Shuang-Feng
- Tetrahedron letters 2017 v.58 no.25 pp. 2433-2437
- alkynes; chemical reactions; copper; esters; isocoumarins; moieties; regioselectivity
- ... An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biologically active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes by copper catalyzed is described. The advantages of this method include mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups. ...