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- Nishitani, Yosuke, et al. Show all 9 Authors
- The British journal of nutrition 2013 v.110 no.5 pp. 880-890
- NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); Saccharina japonica; algae; blood serum; coculture; detection limit; feces; fucoidan; hematologic tests; human cell lines; humans; hydrogen peroxide; ingredients; intestinal mucosa; lutein; messenger RNA; mice; monoclonal antibodies; platelet aggregation; prostacyclin; secretion; thrombosis; volunteers; Japan
- ... Laminaria japonica is traditionally eaten in Japan as a beneficial food for thrombosis. The alga contains two specific ingredients, a xanthophyll fucoxanthin (FX) and a polysaccharide, F-fucoidan (FD). The aim of the present study was to investigate whether FX or FD exhibited anti-thrombotic effects. For this purpose, three types of capsules, containing 1 mg FX, 400 mg fucoidan, and both, were pre ...
- Nishitani, Yosuke, et al. Show all 10 Authors
- The British journal of nutrition 2012 v.107 no.11 pp. 1566-1569
- bioavailability; blood; cis-trans isomers; high performance liquid chromatography; humans; metabolites; mice; oral administration; pharmacokinetics; volunteers
- ... Dietary fucoxanthin has been reported to exert several physiological functions, and fucoxanthinol is considered to be the primary active metabolite of fucoxanthin. However, there is no information about the pharmacokinetics of fucoxanthinol in human subjects. In the present study, eighteen human volunteers were orally administered kombu extract containing 31 mg fucoxanthin, and their peripheral bl ...