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- Heckel, David G.
- The FEBS journal 2016 v.283 no.24 pp. 4458-4461
- Bacillus thuringiensis; electric power; evolution; mechanism of action; plant pests; plant protection; toxins
- ... Pore‐forming toxins from Bacillus thuringiensis are increasingly used in crop protection, but evolution of resistance in crop pests threatens their continued deployment. A study by Tanaka et al. shows how voltage clamp experiments that quantify pore formation can be used to dissect toxin mode of action, thereby revealing unexpected complexities that could be exploited to counter resistance. ...
- Tanaka, Shiho; Endo, Haruka; Adegawa, Satomi; Kikuta, Shingo; Sato, Ryoichi
- The FEBS journal 2016 v.283 no.24 pp. 4474-4490
- ABC transporters; Bacillus thuringiensis; Bombyx mori; Xenopus; aminopeptidases; cations; cell membranes; electric power; insecticides; insects; oligomerization; oocytes; receptors; synergism; toxins; transgenic plants
- ... Bacillus thuringiensis produces Cry toxins, which are used as insecticides in sprays and in transgenic crops. However, little is known about the function of Cry toxin receptors and the mechanisms that determine their binding specificity and activity. In this study, the cRNAs of Bombyx mori ABC transporter C2 (BmABCC2), the toxin‐binding region of cadherin‐like receptor (BtR175‐TBR), or aminopeptid ...