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The Journal of nutritional biochemistry
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2018
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2018 v.59
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- Author:
- Leiferman, Amy; Shu, Jiang; Grove, Ryan; Cui, Juan; Adamec, Jiri; Zempleni, Janos
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 123-128
- ISSN:
- 0955-2863
- Subject:
- cages; cattle; cell culture; dietary nutrient sources; exosomes; feeding behavior; females; food intake; free amino acids; gene expression; gene expression regulation; kidneys; liver; males; messenger RNA; metabolism; mice; milk; muscles; myotubes; nanoparticles; physical activity; renal function; sequence analysis; skeletal muscle
- Abstract:
- ... Exosomes are nanoparticles that transfer cargos from donor cells to recipient cells where they elicit changes in gene expression and metabolism. Evidence suggests that exosomes and their cargos are also absorbed from dietary sources such as bovine milk, and bovine exosomes promote the growth of myofibers in murine C2C12 myotube cell cultures. The aim of the current study was to determine whether t ...
- DOI:
- 10.1016/j.jnutbio.2018.06.007
- PubMed:
- 29986306
- PubMed Central:
- PMC6129415
- https://dx.doi.org/10.1016/j.jnutbio.2018.06.007
- Author:
- Vatsalya, Vatsalya; Kong, Maiying; Cave, Matthew C.; Liu, Nanlong; Schwandt, Melanie L.; George, David T.; Ramchandani, Vijay A.; McClain, Craig J.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 49-55
- ISSN:
- 0955-2863
- Subject:
- C-reactive protein; alanine transaminase; alcohol abuse; alcohol drinking; aspartate transaminase; biomarkers; blood serum; demographic statistics; excretion; females; inflammation; liver; liver diseases; males; nutrient deficiencies; patients; protein content; serum albumin; transporters; zinc
- Abstract:
- ... Zinc deficiency is a frequent complication of alcohol abuse for multiple reasons including poor intake, increased excretion, internal redistribution and altered transporters. Zinc deficiency has been postulated to play a role in the development/progression of alcoholic liver disease (ALD). This study aimed to relate serum zinc levels with alcohol intake, serum albumin concentration and markers of ...
- DOI:
- 10.1016/j.jnutbio.2018.05.003
- PubMed:
- 29960116
- PubMed Central:
- PMC6129416
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.003
- Author:
- Robinson, Jason L.; McBreairty, Laura E.; Randell, Edward W.; Harding, Scott V.; Bartlett, Renee K.; Brunton, Janet A.; Bertolo, Robert F.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 129-135
- ISSN:
- 0955-2863
- Subject:
- betaine; choline; cysteine; diet; folic acid; homocysteine; methionine; neonates; oxidation; piglets; protein deposition; protein synthesis
- Abstract:
- ... Methionine partitioning between protein turnover and a considerable pool of transmethylation precursors is a critical process in the neonate. Transmethylation yields homocysteine, which is either oxidized to cysteine (i.e., transsulfuration), or is remethylated to methionine by folate- or betaine- (from choline) mediated remethylation pathways. The present investigation quantifies the individual a ...
- DOI:
- 10.1016/j.jnutbio.2018.06.001
- https://dx.doi.org/10.1016/j.jnutbio.2018.06.001
- Author:
- Haygert, Priscila; Roversi, Karine; Milanesi, Laura Hautrive; Maurer, Luana Haselein; Camponogara, Camila; Duarte, Thiago; Barcelos, Raquel Cristine S.; Emanuelli, Tatiana; Oliveira, Sara Marchesan; Duarte, Marta Maria Medeiros Frescura; Trevizol, Fabíola; Burger, Marilise Escobar
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 104-113
- ISSN:
- 0955-2863
- Subject:
- Mediterranean diet; Western diets; adulthood; amnesia; cognition; cognitive disorders; dietary fat; hippocampus; histology; interleukin-10; interleukin-1beta; interleukin-6; memory; polyunsaturated fatty acids; processed foods; protective effect; rats; saturated fats; scopolamine; trans fatty acids; tumor necrosis factor-alpha
- Abstract:
- ... A balanced intake of fatty acids (FA) of both omega-6 (n-6) and -3 (n-3) series is essential for memory. The Mediterranean diet (MD), rich in n-3 polyunsaturated FA (PUFA) and low n-6/n-3 PUFA ratio, has shown beneficial influences on health. Inversely, the Western diet contains saturated fats, including hydrogenated vegetable fat (HVF, rich in trans fat) and interesterified fat (IF), making the n ...
- DOI:
- 10.1016/j.jnutbio.2018.05.015
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.015
- Author:
- Chen, Jiali; Yu, Bing; Chen, Daiwen; Huang, Zhiqing; Mao, Xiangbing; Zheng, Ping; Yu, Jie; Luo, Junqiu; He, Jun
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 84-92
- ISSN:
- 0955-2863
- Subject:
- anti-inflammatory activity; antioxidant activity; antioxidants; blood serum; catalase; chlorogenic acid; diamine oxidase; diet; glutathione peroxidase; heme oxygenase (biliverdin-producing); histamine; homeostasis; human nutrition; ileum; inflammation; interleukin-1beta; interleukin-6; intestinal mucosa; jejunum; lactic acid; malondialdehyde; mast cells; models; polyphenols; protective effect; signal transduction; swine; transcription factor NF-kappa B; tryptase; tumor necrosis factor-alpha
- Abstract:
- ... Intestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation and oxidative damage can severely destroy the intestinal integrity of mammals. Chlorogenic acid (CGA) is a natural polyphenol present in human diet and plants, possessing potent antioxidant and anti-inflammatory activities. This study was conducted to investigate the protective effects of CGA and its molecular m ...
- DOI:
- 10.1016/j.jnutbio.2018.06.005
- https://dx.doi.org/10.1016/j.jnutbio.2018.06.005
- Author:
- Ruan, Jing-Syuna; Lin, Jie-Kuan; Kuo, Yi-Ying; Chen, Yun-Wen; Chen, Pei-Chun
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 37-48
- ISSN:
- 0955-2863
- Subject:
- adenosine triphosphate; apoptosis; caspase-3; free fatty acids; glibenclamide; glucose; glucose tolerance; insulin resistance; insulin secretion; islets of Langerhans; lipotoxicity; mice; palmitic acid; potassium; potassium channels; protein content; triacylglycerols
- Abstract:
- ... Lipotoxicity is associated with a high level of fatty acid accumulation in pancreatic β-cells. An overload of free fatty acids contributes to pancreatic β-cell apoptosis and dysfunction. Insulin secretion involves sequential ionic events upon glucose stimulation. ATP sensitive potassium (KATP) channels serve as glucose sensors and effectively initiate glucose-stimulated insulin secretion. This stu ...
- DOI:
- 10.1016/j.jnutbio.2018.05.005
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.005
- Author:
- Wang, Tao; Xiang, Ping; Ha, Jung-Heun; Wang, Xiaoyu; Doguer, Caglar; Flores, Shireen R.L.; Kang, Yujian James; Collins, James F.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 56-63
- ISSN:
- 0955-2863
- Subject:
- absorption; anemia; blood serum; copper; diet; drinking water; ferroxidase; heart; hypertrophy; intestines; iron; iron overload; mice; weanlings
- Abstract:
- ... Dietary iron overload in rodents impairs growth and causes cardiac hypertrophy, serum and tissue copper depletion, depression of serum ceruloplasmin (Cp) activity and anemia. Notably, increasing dietary copper content to ~25-fold above requirements prevents the development of these physiological perturbations. Whether copper supplementation can reverse these high-iron-related abnormalities has, ho ...
- DOI:
- 10.1016/j.jnutbio.2018.05.006
- PubMed:
- 29960117
- PubMed Central:
- PMC6467079
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.006
- Author:
- Chen, Yi-Yung; Gupta, Madhulika B.; Grattton, Rob; Powell, Theresa L.; Jansson, Thomas
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 136-141
- ISSN:
- 0955-2863
- Subject:
- Western blotting; adults; birth weight; childhood; fetal development; filtration; folic acid; folic acid transporters; gestational age; neural tube defects; placenta; plasma membrane; pregnancy; protein synthesis; radiolabeling; vitamin B deficiency; women
- Abstract:
- ... Folate deficiency in pregnancy is associated with neural tube defects, restricted fetal growth and fetal programming of diseases later in life. Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-α and Reduced Folate Carrier (RFC). We tested the hypothesis that intrauterine growth restriction (I ...
- DOI:
- 10.1016/j.jnutbio.2018.06.003
- PubMed:
- 29986308
- PubMed Central:
- PMC6129407
- https://dx.doi.org/10.1016/j.jnutbio.2018.06.003
- Author:
- Li, Wei; Tang, Renqiao; Ma, Feifei; Ouyang, Shengrong; Liu, Zhuo; Wu, Jianxin
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 76-83
- ISSN:
- 0955-2863
- Subject:
- DNA methylation; adipocytes; adipose tissue; animal disease models; blood glucose; drinking water; epididymis; folic acid; genes; glucose; high fat diet; insulin; insulin resistance; insulin secretion; mice; noninsulin-dependent diabetes mellitus; obesity; precipitin tests
- Abstract:
- ... Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders are not well elucidated. We adopted a genome-wide approach to directly examine whether FA supplementation affects the DNA methylation profile of mouse adipose tissue and identify the functional consequences of these ch ...
- DOI:
- 10.1016/j.jnutbio.2018.05.010
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.010
- Author:
- Montalvany-Antonucci, Carina Cristina; Zicker, Marina Campos; Ferreira, Adaliene Versiani Matos; Macari, Soraia; Ramos-Junior, Erivan Schnaider; Gomez, Ricardo Santiago; Pereira, Thaís Santos Ferreira; Madeira, Mila Fernandes Moreira; Fukada, Sandra Yasuyo; Andrade, Ildeu; Silva, Tarcília Aparecida
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 93-103
- ISSN:
- 0955-2863
- Subject:
- adipocytes; adipokines; adiposity; blood; bone resorption; coculture; femur; gene expression; genes; high fat diet; inflammation; mice; osteoblasts; osteoclasts; patients; phenotype; resorption; white adipose tissue
- Abstract:
- ... A high-fat (HF) diet leads to detrimental effects on alveolar bone (AB); however, the mechanisms linking adiposity to bone loss are poorly understood. This study investigated if AB resorption induced by an HF diet is associated with the regulation of inflammatory gene expression and if adipocytes can directly interfere with osteoclastogenesis. We also evaluated the effects of diet restriction (DR) ...
- DOI:
- 10.1016/j.jnutbio.2018.06.006
- https://dx.doi.org/10.1016/j.jnutbio.2018.06.006
- Author:
- Mayta-Apaza, Alba C.; Pottgen, Ellen; De Bodt, Jana; Papp, Nora; Marasini, Daya; Howard, Luke; Abranko, Laszlo; Van de Wiele, Tom; Lee, Sun-Ok; Carbonero, Franck
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 160-172
- ISSN:
- 0955-2863
- Subject:
- 4-hydroxybenzoic acid; Bacteroides; Bifidobacterium; Collinsella; Lachnospiraceae; Prevotella; Prunus cerasus; Ruminococcus; anthocyanins; apricots; cherries; chlorogenic acid; epicatechin; fermentation; humans; intestinal microorganisms; juice concentrates; metabolites; metabolomics; nucleotide sequences; nutritional intervention; polyphenols; polysaccharides; prebiotics; ribosomal RNA
- Abstract:
- ... Tart cherries have been reported to exert potential health benefits attributed to their specific and abundant polyphenol content. However, there is a need to study the impact and fate of tart cherries polyphenols in the gut microbiota. Here, tart cherries, pure polyphenols (and apricots) were submitted to in vitro bacterial fermentation assays and assessed through 16S rRNA gene sequence sequencing ...
- DOI:
- 10.1016/j.jnutbio.2018.04.001
- https://dx.doi.org/10.1016/j.jnutbio.2018.04.001
- Author:
- Salinas-Rubio, Daniela; Tovar, Armando R.; Torre-Villalvazo, Iván; Granados-Portillo, Omar; Torres, Nimbe; Pedraza-Chaverri, José; Noriega, Lilia G.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 29-36
- ISSN:
- 0955-2863
- Subject:
- adipocytes; animal disease models; free fatty acids; high fat diet; insulin resistance; leucine; lipids; metabolism; metabolomics; obesity; oxidation; palmitates; phenotype; proteins; rats
- Abstract:
- ... Metabolic profiling studies have highlighted increases in the plasma free fatty acid (FFA) and branched-chain amino acid (BCAA) concentrations, which are hallmarks of the obese and insulin-resistant phenotype. However, little is known about how the increase of the BCAA concentration modifies the metabolic fate of FFA, and vice versa, in adipocytes. Therefore, we incubated differentiated 3T3-L1 adi ...
- DOI:
- 10.1016/j.jnutbio.2018.05.011
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.011
- Author:
- Miyamoto, Josiane Érica; Ferraz, Ana Carolina G.; Portovedo, Mariana; Reginato, Andressa; Stahl, Marcella Aparecida; Ignacio-Souza, Leticia Martins; Chan, Kenny L.; Torsoni, Adriana Souza; Torsoni, Marcio Alberto; Ribeiro, Ana Paula Badan; Milanski, Marciane
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 153-159
- ISSN:
- 0955-2863
- Subject:
- adiposity; economic sustainability; food industry; gene expression; glucose; glucose tolerance; high fat diet; inflammation; laboratory animals; lard; liver; males; rats; soybean oil; trans fatty acids; weight gain
- Abstract:
- ... Interesterified fats have largely replaced hydrogenated vegetable fat, which is rich in trans fatty acids, in the food industry as an economically viable alternative, generating interest to study their health effects. The aim of this study was to evaluate the effect that interesterification of oils and fat has on lipid-induced metabolic dysfunction, hepatic inflammation and ER stress. Five week-ol ...
- DOI:
- 10.1016/j.jnutbio.2018.05.014
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.014
- Author:
- Singh, Arashdeep; Zapata, Rizaldy C.; Pezeshki, Adel; Reidelberger, Roger D.; Chelikani, Prasanth K.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 142-152
- ISSN:
- 0955-2863
- Subject:
- Bacteroidetes; Bifidobacterium; Clostridium; adiposity; cecum; cellulose; cholecystokinin; colon; dose response; energy expenditure; energy intake; food choices; food intake; glucagon-like peptide 1; glucose tolerance; high fat diet; high fiber diet; intestinal microorganisms; inulin; low calorie diet; males; peptide YY; prebiotics; rats; respiratory quotient; satiety; transferases; undereating
- Abstract:
- ... Inulin, a popular prebiotic fiber, has been reported to promote satiety and fat loss; however, the dose–response effects of inulin on energy balance and diet preference, and whether the metabolic effects are independent of calorie restriction are not well characterized. Therefore, we compared the effects of diets varying in inulin concentrations on food intake, energy expenditure, body composition ...
- DOI:
- 10.1016/j.jnutbio.2018.05.017
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.017
- Author:
- Zhou, Miao-miao; Ding, Lin; Wen, Min; Che, Hong-xia; Huang, Jia-qi; Zhang, Tian-tian; Xue, Chang-hu; Mao, Xiang-zhao; Wang, Yu-ming
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 64-75
- ISSN:
- 0955-2863
- Subject:
- Alzheimer disease; apoptosis; cognition; cognitive disorders; high fat diet; metabolic diseases; mice; mitochondria; models; neurotrophins; obesity; oxidative stress; phospholipids
- Abstract:
- ... Recent studies have shown that a high-fat diet (HFD) is involved in both metabolic dysfunction and cognitive deficiency and that docosahexaenoic-acid-enriched phospholipids (DHA-PLs) have beneficial effects on obesity and cognitive impairment. However, there are only a few studies comparing differences between DHA-PC and DHA-PS in HFD-induced Alzheimer's disease (AD) models. After 8 weeks feeding ...
- DOI:
- 10.1016/j.jnutbio.2018.05.009
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.009
- Author:
- Kim, Jae Kyeom; Park, Jung Hyun; Ku, Hyeong Jun; Kim, Sung Hwan; Lim, Ye Jin; Park, Jeen Woo; Lee, Jin Hyup
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 10-16
- ISSN:
- 0955-2863
- Subject:
- DNA damage; acrolein; apoptosis; breathing; inflammation; interleukin-1beta; lung neoplasms; lungs; males; mice; mitogen-activated protein kinase; naringin; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Acrolein (2-propenal) is ubiquitous in the environment and connections exist between acrolein exposure and lung cancer risk. Here we investigated the effects of naringin on acrolein induced-lung injuries in mice. Male C57BL/6 mice were allocated into four groups: Vehicle group (no acrolein), Naringin only group (80 mg of naringin/kg bw + no acrolein), Acrolein group (ACR group; acrolein), and Nari ...
- DOI:
- 10.1016/j.jnutbio.2018.05.012
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.012
- Author:
- Gaffney-Stomberg, Erin; Marszewski, Phillip; MacArthur, Michael; McClung, James P.; Matheny, Ronald W.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 114-122
- ISSN:
- 0955-2863
- Subject:
- absorption; bone health; calcium; culture media; high protein diet; homeostasis; human cell lines; intestinal mucosa; leucine; lysine; models; phenylalanine; raffinose; signal transduction; tight junctions
- Abstract:
- ... High-protein diets are generally considered beneficial for calcium (Ca) economy and bone health. Improved intestinal Ca absorption efficiency may be one mechanism by which higher-protein diets affect Ca homeostasis and bone health. The signaling pathways and individual amino acids (AA) responsible for this effect have not been fully elucidated and may involve the transcellular pathway, paracellula ...
- DOI:
- 10.1016/j.jnutbio.2018.04.017
- https://dx.doi.org/10.1016/j.jnutbio.2018.04.017
- Author:
- Malliou, Foteini; Andreadou, Ioanna; Gonzalez, Frank J.; Lazou, Antigone; Xepapadaki, Eva; Vallianou, Ioanna; Lambrinidis, George; Mikros, Emmanuel; Marselos, Marios; Skaltsounis, Alexios-Leandros; Konstandi, Maria
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 17-28
- ISSN:
- 0955-2863
- Subject:
- adults; agonists; antioxidants; blood serum; carboxylic ester hydrolases; cholesterol; computer simulation; energy; gene expression; gene expression regulation; homeostasis; infarction; ligands; lipemic effect; liver; luciferase; males; metabolism; mice; oleuropein; olives; peroxisome proliferator-activated receptor alpha; rabbits; reporter genes; triacylglycerols; white adipose tissue
- Abstract:
- ... Oleuropein (OLE), a main constituent of olive, exhibits antioxidant and hypolipidemic effects, while it reduces the infarct size in chow- and cholesterol-fed rabbits. Peroxisome proliferator-activated receptor α (PPARα) has essential roles in the control of lipid metabolism and energy homeostasis. This study focused on the mechanisms underlying the hypolipidemic activity of OLE and, specifically, ...
- DOI:
- 10.1016/j.jnutbio.2018.05.013
- PubMed:
- 29960113
- PubMed Central:
- PMC6628917
- https://dx.doi.org/10.1016/j.jnutbio.2018.05.013
- Author:
- Jain, Raghav; Austin Pickens, C.; Fenton, Jenifer I.
- Source:
- The Journal of nutritional biochemistry 2018 v.59 pp. 1-9
- ISSN:
- 0955-2863
- Subject:
- adipocytes; anti-inflammatory activity; apoptosis; arachidonic acid; biomarkers; carcinogenesis; cell growth; colon; colorectal neoplasms; cytochrome P-450; endothelial cells; gangliosides; inflammation; lipid metabolism; metabolites; neoplasm cells; obesity; prostaglandin synthase; prostaglandins; risk; therapeutics
- Abstract:
- ... Obesity is a state of chronic inflammation influenced by lipids such as fatty acids and their secondary oxygenated metabolites deemed oxylipids. Many such lipid mediators serve as potent signaling molecules of inflammation, which can further alter lipid metabolism and lead to carcinogenesis. For example, sphingosine-1-phosphate activates cyclooxygenase-2 in endothelial cells resulting in the conve ...
- DOI:
- 10.1016/j.jnutbio.2018.02.015
- https://dx.doi.org/10.1016/j.jnutbio.2018.02.015