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You searched for: Journal The Journal of nutritional biochemistry Remove constraint Journal: The Journal of nutritional biochemistry Publication Year 2018 Remove constraint Publication Year: 2018 Source 2018 v.59 Remove constraint Source: 2018 v.59
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1. A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice

Author:
Leiferman, Amy; Shu, Jiang; Grove, Ryan; Cui, Juan; Adamec, Jiri; Zempleni, Janos
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 123-128
ISSN:
0955-2863
Subject:
cages; cattle; cell culture; dietary nutrient sources; exosomes; feeding behavior; females; food intake; free amino acids; gene expression; gene expression regulation; kidneys; liver; males; messenger RNA; metabolism; mice; milk; muscles; myotubes; nanoparticles; physical activity; renal function; sequence analysis; skeletal muscle
Abstract:
... Exosomes are nanoparticles that transfer cargos from donor cells to recipient cells where they elicit changes in gene expression and metabolism. Evidence suggests that exosomes and their cargos are also absorbed from dietary sources such as bovine milk, and bovine exosomes promote the growth of myofibers in murine C2C12 myotube cell cultures. The aim of the current study was to determine whether t ...
DOI:
10.1016/j.jnutbio.2018.06.007
PubMed:
29986306
PubMed Central:
PMC6129415

2. Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients

Author:
Vatsalya, Vatsalya; Kong, Maiying; Cave, Matthew C.; Liu, Nanlong; Schwandt, Melanie L.; George, David T.; Ramchandani, Vijay A.; McClain, Craig J.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 49-55
ISSN:
0955-2863
Subject:
C-reactive protein; alanine transaminase; alcohol abuse; alcohol drinking; aspartate transaminase; biomarkers; blood serum; demographic statistics; excretion; females; inflammation; liver; liver diseases; males; nutrient deficiencies; patients; protein content; serum albumin; transporters; zinc
Abstract:
... Zinc deficiency is a frequent complication of alcohol abuse for multiple reasons including poor intake, increased excretion, internal redistribution and altered transporters. Zinc deficiency has been postulated to play a role in the development/progression of alcoholic liver disease (ALD). This study aimed to relate serum zinc levels with alcohol intake, serum albumin concentration and markers of ...
DOI:
10.1016/j.jnutbio.2018.05.003
PubMed:
29960116
PubMed Central:
PMC6129416

3. Betaine or folate can equally furnish remethylation to methionine and increase transmethylation in methionine-restricted neonates

Author:
Robinson, Jason L.; McBreairty, Laura E.; Randell, Edward W.; Harding, Scott V.; Bartlett, Renee K.; Brunton, Janet A.; Bertolo, Robert F.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 129-135
ISSN:
0955-2863
Subject:
betaine; choline; cysteine; diet; folic acid; homocysteine; methionine; neonates; oxidation; piglets; protein deposition; protein synthesis
Abstract:
... Methionine partitioning between protein turnover and a considerable pool of transmethylation precursors is a critical process in the neonate. Transmethylation yields homocysteine, which is either oxidized to cysteine (i.e., transsulfuration), or is remethylated to methionine by folate- or betaine- (from choline) mediated remethylation pathways. The present investigation quantifies the individual a ...
DOI:
10.1016/j.jnutbio.2018.06.001

4. Can the dietary fat type facilitate memory impairments in adulthood? A comparative study between Mediterranean and Western-based diet in rats

Author:
Haygert, Priscila; Roversi, Karine; Milanesi, Laura Hautrive; Maurer, Luana Haselein; Camponogara, Camila; Duarte, Thiago; Barcelos, Raquel Cristine S.; Emanuelli, Tatiana; Oliveira, Sara Marchesan; Duarte, Marta Maria Medeiros Frescura; Trevizol, Fabíola; Burger, Marilise Escobar
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 104-113
ISSN:
0955-2863
Subject:
Mediterranean diet; Western diets; adulthood; amnesia; cognition; cognitive disorders; dietary fat; hippocampus; histology; interleukin-10; interleukin-1beta; interleukin-6; memory; polyunsaturated fatty acids; processed foods; protective effect; rats; saturated fats; scopolamine; trans fatty acids; tumor necrosis factor-alpha
Abstract:
... A balanced intake of fatty acids (FA) of both omega-6 (n-6) and -3 (n-3) series is essential for memory. The Mediterranean diet (MD), rich in n-3 polyunsaturated FA (PUFA) and low n-6/n-3 PUFA ratio, has shown beneficial influences on health. Inversely, the Western diet contains saturated fats, including hydrogenated vegetable fat (HVF, rich in trans fat) and interesterified fat (IF), making the n ...
DOI:
10.1016/j.jnutbio.2018.05.015

5. Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs

Author:
Chen, Jiali; Yu, Bing; Chen, Daiwen; Huang, Zhiqing; Mao, Xiangbing; Zheng, Ping; Yu, Jie; Luo, Junqiu; He, Jun
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 84-92
ISSN:
0955-2863
Subject:
anti-inflammatory activity; antioxidant activity; antioxidants; blood serum; catalase; chlorogenic acid; diamine oxidase; diet; glutathione peroxidase; heme oxygenase (biliverdin-producing); histamine; homeostasis; human nutrition; ileum; inflammation; interleukin-1beta; interleukin-6; intestinal mucosa; jejunum; lactic acid; malondialdehyde; mast cells; models; polyphenols; protective effect; signal transduction; swine; transcription factor NF-kappa B; tryptase; tumor necrosis factor-alpha
Abstract:
... Intestinal barrier plays key roles in maintaining intestinal homeostasis. Inflammation and oxidative damage can severely destroy the intestinal integrity of mammals. Chlorogenic acid (CGA) is a natural polyphenol present in human diet and plants, possessing potent antioxidant and anti-inflammatory activities. This study was conducted to investigate the protective effects of CGA and its molecular m ...
DOI:
10.1016/j.jnutbio.2018.06.005

6. Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic β cells

Author:
Ruan, Jing-Syuna; Lin, Jie-Kuan; Kuo, Yi-Ying; Chen, Yun-Wen; Chen, Pei-Chun
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 37-48
ISSN:
0955-2863
Subject:
adenosine triphosphate; apoptosis; caspase-3; free fatty acids; glibenclamide; glucose; glucose tolerance; insulin resistance; insulin secretion; islets of Langerhans; lipotoxicity; mice; palmitic acid; potassium; potassium channels; protein content; triacylglycerols
Abstract:
... Lipotoxicity is associated with a high level of fatty acid accumulation in pancreatic β-cells. An overload of free fatty acids contributes to pancreatic β-cell apoptosis and dysfunction. Insulin secretion involves sequential ionic events upon glucose stimulation. ATP sensitive potassium (KATP) channels serve as glucose sensors and effectively initiate glucose-stimulated insulin secretion. This stu ...
DOI:
10.1016/j.jnutbio.2018.05.005

7. Copper supplementation reverses dietary iron overload-induced pathologies in mice

Author:
Wang, Tao; Xiang, Ping; Ha, Jung-Heun; Wang, Xiaoyu; Doguer, Caglar; Flores, Shireen R.L.; Kang, Yujian James; Collins, James F.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 56-63
ISSN:
0955-2863
Subject:
absorption; anemia; blood serum; copper; diet; drinking water; ferroxidase; heart; hypertrophy; intestines; iron; iron overload; mice; weanlings
Abstract:
... Dietary iron overload in rodents impairs growth and causes cardiac hypertrophy, serum and tissue copper depletion, depression of serum ceruloplasmin (Cp) activity and anemia. Notably, increasing dietary copper content to ~25-fold above requirements prevents the development of these physiological perturbations. Whether copper supplementation can reverse these high-iron-related abnormalities has, ho ...
DOI:
10.1016/j.jnutbio.2018.05.006
PubMed:
29960117
PubMed Central:
PMC6467079

8. Down-regulation of placental folate transporters in intrauterine growth restriction

Author:
Chen, Yi-Yung; Gupta, Madhulika B.; Grattton, Rob; Powell, Theresa L.; Jansson, Thomas
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 136-141
ISSN:
0955-2863
Subject:
Western blotting; adults; birth weight; childhood; fetal development; filtration; folic acid; folic acid transporters; gestational age; neural tube defects; placenta; plasma membrane; pregnancy; protein synthesis; radiolabeling; vitamin B deficiency; women
Abstract:
... Folate deficiency in pregnancy is associated with neural tube defects, restricted fetal growth and fetal programming of diseases later in life. Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-α and Reduced Folate Carrier (RFC). We tested the hypothesis that intrauterine growth restriction (I ...
DOI:
10.1016/j.jnutbio.2018.06.003
PubMed:
29986308
PubMed Central:
PMC6129407

9. Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice

Author:
Li, Wei; Tang, Renqiao; Ma, Feifei; Ouyang, Shengrong; Liu, Zhuo; Wu, Jianxin
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 76-83
ISSN:
0955-2863
Subject:
DNA methylation; adipocytes; adipose tissue; animal disease models; blood glucose; drinking water; epididymis; folic acid; genes; glucose; high fat diet; insulin; insulin resistance; insulin secretion; mice; noninsulin-dependent diabetes mellitus; obesity; precipitin tests
Abstract:
... Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders are not well elucidated. We adopted a genome-wide approach to directly examine whether FA supplementation affects the DNA methylation profile of mouse adipose tissue and identify the functional consequences of these ch ...
DOI:
10.1016/j.jnutbio.2018.05.010

10. High-fat diet disrupts bone remodeling by inducing local and systemic alterations

Author:
Montalvany-Antonucci, Carina Cristina; Zicker, Marina Campos; Ferreira, Adaliene Versiani Matos; Macari, Soraia; Ramos-Junior, Erivan Schnaider; Gomez, Ricardo Santiago; Pereira, Thaís Santos Ferreira; Madeira, Mila Fernandes Moreira; Fukada, Sandra Yasuyo; Andrade, Ildeu; Silva, Tarcília Aparecida
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 93-103
ISSN:
0955-2863
Subject:
adipocytes; adipokines; adiposity; blood; bone resorption; coculture; femur; gene expression; genes; high fat diet; inflammation; mice; osteoblasts; osteoclasts; patients; phenotype; resorption; white adipose tissue
Abstract:
... A high-fat (HF) diet leads to detrimental effects on alveolar bone (AB); however, the mechanisms linking adiposity to bone loss are poorly understood. This study investigated if AB resorption induced by an HF diet is associated with the regulation of inflammatory gene expression and if adipocytes can directly interfere with osteoclastogenesis. We also evaluated the effects of diet restriction (DR) ...
DOI:
10.1016/j.jnutbio.2018.06.006

11. Impact of tart cherries polyphenols on the human gut microbiota and phenolic metabolites in vitro and in vivo

Author:
Mayta-Apaza, Alba C.; Pottgen, Ellen; De Bodt, Jana; Papp, Nora; Marasini, Daya; Howard, Luke; Abranko, Laszlo; Van de Wiele, Tom; Lee, Sun-Ok; Carbonero, Franck
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 160-172
ISSN:
0955-2863
Subject:
4-hydroxybenzoic acid; Bacteroides; Bifidobacterium; Collinsella; Lachnospiraceae; Prevotella; Prunus cerasus; Ruminococcus; anthocyanins; apricots; cherries; chlorogenic acid; epicatechin; fermentation; humans; intestinal microorganisms; juice concentrates; metabolites; metabolomics; nucleotide sequences; nutritional intervention; polyphenols; polysaccharides; prebiotics; ribosomal RNA
Abstract:
... Tart cherries have been reported to exert potential health benefits attributed to their specific and abundant polyphenol content. However, there is a need to study the impact and fate of tart cherries polyphenols in the gut microbiota. Here, tart cherries, pure polyphenols (and apricots) were submitted to in vitro bacterial fermentation assays and assessed through 16S rRNA gene sequence sequencing ...
DOI:
10.1016/j.jnutbio.2018.04.001

12. Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats

Author:
Salinas-Rubio, Daniela; Tovar, Armando R.; Torre-Villalvazo, Iván; Granados-Portillo, Omar; Torres, Nimbe; Pedraza-Chaverri, José; Noriega, Lilia G.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 29-36
ISSN:
0955-2863
Subject:
adipocytes; animal disease models; free fatty acids; high fat diet; insulin resistance; leucine; lipids; metabolism; metabolomics; obesity; oxidation; palmitates; phenotype; proteins; rats
Abstract:
... Metabolic profiling studies have highlighted increases in the plasma free fatty acid (FFA) and branched-chain amino acid (BCAA) concentrations, which are hallmarks of the obese and insulin-resistant phenotype. However, little is known about how the increase of the BCAA concentration modifies the metabolic fate of FFA, and vice versa, in adipocytes. Therefore, we incubated differentiated 3T3-L1 adi ...
DOI:
10.1016/j.jnutbio.2018.05.011

13. Interesterified soybean oil promotes weight gain, impaired glucose tolerance and increased liver cellular stress markers

Author:
Miyamoto, Josiane Érica; Ferraz, Ana Carolina G.; Portovedo, Mariana; Reginato, Andressa; Stahl, Marcella Aparecida; Ignacio-Souza, Leticia Martins; Chan, Kenny L.; Torsoni, Adriana Souza; Torsoni, Marcio Alberto; Ribeiro, Ana Paula Badan; Milanski, Marciane
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 153-159
ISSN:
0955-2863
Subject:
adiposity; economic sustainability; food industry; gene expression; glucose; glucose tolerance; high fat diet; inflammation; laboratory animals; lard; liver; males; rats; soybean oil; trans fatty acids; weight gain
Abstract:
... Interesterified fats have largely replaced hydrogenated vegetable fat, which is rich in trans fatty acids, in the food industry as an economically viable alternative, generating interest to study their health effects. The aim of this study was to evaluate the effect that interesterification of oils and fat has on lipid-induced metabolic dysfunction, hepatic inflammation and ER stress. Five week-ol ...
DOI:
10.1016/j.jnutbio.2018.05.014

14. Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat-fed male rats

Author:
Singh, Arashdeep; Zapata, Rizaldy C.; Pezeshki, Adel; Reidelberger, Roger D.; Chelikani, Prasanth K.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 142-152
ISSN:
0955-2863
Subject:
Bacteroidetes; Bifidobacterium; Clostridium; adiposity; cecum; cellulose; cholecystokinin; colon; dose response; energy expenditure; energy intake; food choices; food intake; glucagon-like peptide 1; glucose tolerance; high fat diet; high fiber diet; intestinal microorganisms; inulin; low calorie diet; males; peptide YY; prebiotics; rats; respiratory quotient; satiety; transferases; undereating
Abstract:
... Inulin, a popular prebiotic fiber, has been reported to promote satiety and fat loss; however, the dose–response effects of inulin on energy balance and diet preference, and whether the metabolic effects are independent of calorie restriction are not well characterized. Therefore, we compared the effects of diets varying in inulin concentrations on food intake, energy expenditure, body composition ...
DOI:
10.1016/j.jnutbio.2018.05.017

15. Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet

Author:
Zhou, Miao-miao; Ding, Lin; Wen, Min; Che, Hong-xia; Huang, Jia-qi; Zhang, Tian-tian; Xue, Chang-hu; Mao, Xiang-zhao; Wang, Yu-ming
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 64-75
ISSN:
0955-2863
Subject:
Alzheimer disease; apoptosis; cognition; cognitive disorders; high fat diet; metabolic diseases; mice; mitochondria; models; neurotrophins; obesity; oxidative stress; phospholipids
Abstract:
... Recent studies have shown that a high-fat diet (HFD) is involved in both metabolic dysfunction and cognitive deficiency and that docosahexaenoic-acid-enriched phospholipids (DHA-PLs) have beneficial effects on obesity and cognitive impairment. However, there are only a few studies comparing differences between DHA-PC and DHA-PS in HFD-induced Alzheimer's disease (AD) models. After 8 weeks feeding ...
DOI:
10.1016/j.jnutbio.2018.05.009

16. Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice

Author:
Kim, Jae Kyeom; Park, Jung Hyun; Ku, Hyeong Jun; Kim, Sung Hwan; Lim, Ye Jin; Park, Jeen Woo; Lee, Jin Hyup
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 10-16
ISSN:
0955-2863
Subject:
DNA damage; acrolein; apoptosis; breathing; inflammation; interleukin-1beta; lung neoplasms; lungs; males; mice; mitogen-activated protein kinase; naringin; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Acrolein (2-propenal) is ubiquitous in the environment and connections exist between acrolein exposure and lung cancer risk. Here we investigated the effects of naringin on acrolein induced-lung injuries in mice. Male C57BL/6 mice were allocated into four groups: Vehicle group (no acrolein), Naringin only group (80 mg of naringin/kg bw + no acrolein), Acrolein group (ACR group; acrolein), and Nari ...
DOI:
10.1016/j.jnutbio.2018.05.012

17. Paracellular calcium flux across Caco-2 cell monolayers: Effects of individual amino acids

Author:
Gaffney-Stomberg, Erin; Marszewski, Phillip; MacArthur, Michael; McClung, James P.; Matheny, Ronald W.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 114-122
ISSN:
0955-2863
Subject:
absorption; bone health; calcium; culture media; high protein diet; homeostasis; human cell lines; intestinal mucosa; leucine; lysine; models; phenylalanine; raffinose; signal transduction; tight junctions
Abstract:
... High-protein diets are generally considered beneficial for calcium (Ca) economy and bone health. Improved intestinal Ca absorption efficiency may be one mechanism by which higher-protein diets affect Ca homeostasis and bone health. The signaling pathways and individual amino acids (AA) responsible for this effect have not been fully elucidated and may involve the transcellular pathway, paracellula ...
DOI:
10.1016/j.jnutbio.2018.04.017

18. The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides

Author:
Malliou, Foteini; Andreadou, Ioanna; Gonzalez, Frank J.; Lazou, Antigone; Xepapadaki, Eva; Vallianou, Ioanna; Lambrinidis, George; Mikros, Emmanuel; Marselos, Marios; Skaltsounis, Alexios-Leandros; Konstandi, Maria
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 17-28
ISSN:
0955-2863
Subject:
adults; agonists; antioxidants; blood serum; carboxylic ester hydrolases; cholesterol; computer simulation; energy; gene expression; gene expression regulation; homeostasis; infarction; ligands; lipemic effect; liver; luciferase; males; metabolism; mice; oleuropein; olives; peroxisome proliferator-activated receptor alpha; rabbits; reporter genes; triacylglycerols; white adipose tissue
Abstract:
... Oleuropein (OLE), a main constituent of olive, exhibits antioxidant and hypolipidemic effects, while it reduces the infarct size in chow- and cholesterol-fed rabbits. Peroxisome proliferator-activated receptor α (PPARα) has essential roles in the control of lipid metabolism and energy homeostasis. This study focused on the mechanisms underlying the hypolipidemic activity of OLE and, specifically, ...
DOI:
10.1016/j.jnutbio.2018.05.013
PubMed:
29960113
PubMed Central:
PMC6628917

19. The role of the lipidome in obesity-mediated colon cancer risk

Author:
Jain, Raghav; Austin Pickens, C.; Fenton, Jenifer I.
Source:
The Journal of nutritional biochemistry 2018 v.59 pp. 1-9
ISSN:
0955-2863
Subject:
adipocytes; anti-inflammatory activity; apoptosis; arachidonic acid; biomarkers; carcinogenesis; cell growth; colon; colorectal neoplasms; cytochrome P-450; endothelial cells; gangliosides; inflammation; lipid metabolism; metabolites; neoplasm cells; obesity; prostaglandin synthase; prostaglandins; risk; therapeutics
Abstract:
... Obesity is a state of chronic inflammation influenced by lipids such as fatty acids and their secondary oxygenated metabolites deemed oxylipids. Many such lipid mediators serve as potent signaling molecules of inflammation, which can further alter lipid metabolism and lead to carcinogenesis. For example, sphingosine-1-phosphate activates cyclooxygenase-2 in endothelial cells resulting in the conve ...
DOI:
10.1016/j.jnutbio.2018.02.015