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- Zhao, Hong; Zhao, Xingcheng; Liu, Lijuan; Zhang, Hongxu; Xuan, Mingwen; Guo, Zhaohui; Wang, Hongcai; Liu, Chang
- The international journal of biochemistry & cell biology 2017 v.87 pp. 86-94
- Parkinson disease; Western blotting; adenosine triphosphate; adjuvants; apoptosis; autophagy; cell viability; cytotoxicity; dopamine; enzyme-linked immunosorbent assay; fluorescence; gene expression; lipoic acid; mitochondria; models; protective effect; reactive oxygen species; regulatory proteins; staining
- ... Parkinson’s disease (PD) is a common neurodegenerative disease. This study aimed to investigate the effects of the R form of α-lipoic acid (RLA) in cellular models of PD induced by 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Cell viability and apoptosis were detected using CCK8 and Annexin V-FITC assays, respectively. Intracellular reactive oxygen species (ROS ...