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You searched for: Subject "G-protein coupled receptors" Remove constraint Subject: "G-protein coupled receptors" Journal The international journal of biochemistry & cell biology Remove constraint Journal: The international journal of biochemistry & cell biology Publication Year 2016 Remove constraint Publication Year: 2016 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Structural modeling of G-protein coupled receptors: An overview on automatic web-servers

Author:
Busato, Mirko; Giorgetti, Alejandro
Source:
The international journal of biochemistry & cell biology 2016 v.77 pp. 264-274
ISSN:
1357-2725
Subject:
G-protein coupled receptors,   etc   ; crystallization; crystallography; databases; humans; models; prediction;     Show all 7 Subjects
Abstract:
... Despite the significant efforts and discoveries during the last few years in G protein-coupled receptor (GPCR) expression and crystallization, the receptors with known structures to date are limited only to a small fraction of human GPCRs. The lack of experimental three-dimensional structures of the receptors represents a strong limitation that hampers a deep understanding of their function. Compu ...
DOI:
10.1016/j.biocel.2016.04.004

2. Inside story of Group I Metabotropic Glutamate Receptors (mGluRs)

Author:
Bhattacharyya, Samarjit
Source:
The international journal of biochemistry & cell biology 2016 v.77 pp. 205-212
ISSN:
1357-2725
Subject:
G-protein coupled receptors,   etc   ; autism; brain; glutamate receptors; glutamic acid; memory; neurons; neuroplasticity; neurotransmitters; physiological transport;     Show all 10 Subjects
Abstract:
... Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are activated by the neurotransmitter glutamate in the central nervous system. Among the eight subtypes, mGluR1 and mGluR5 belong to the group I family. These receptors play important roles in the brain and are believed to be involved in multiple forms of experience dependent synaptic plasticity including learni ...
DOI:
10.1016/j.biocel.2016.03.003

3. Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders

Author:
Dogra, Shalini; Sona, Chandan; Kumar, Ajeet; Yadav, Prem N.
Source:
The international journal of biochemistry & cell biology 2016 v.77 pp. 226-239
ISSN:
1357-2725
Subject:
G-protein coupled receptors,   etc   ; behavior disorders; central nervous system; epigenetics; etiology; genes; nervous system diseases; neurotransmitters; pain; pathophysiology; pharmacogenomics; therapeutics;     Show all 12 Subjects
Abstract:
... G protein-coupled receptors (GPCRs) act as a relay center through which extracellular signals, in the form of neurotransmitters or therapeutics, are converted into an intracellular response, which ultimately shapes the overall response at the tissue and behavioral level. Remarkably in similar ways, epigenetic mechanisms also modulate the expression pattern of a large number of genes in response to ...
DOI:
10.1016/j.biocel.2016.03.012

4. The role of G protein-coupled receptors in cochlear planar cell polarity

Author:
Sun, Jinpeng; Zhang, Daolai; Wang, Yanfei; Lin, Hal; Yu, Xiao; Xu, Zhigang
Source:
The international journal of biochemistry & cell biology 2016 v.77 pp. 220-225
ISSN:
1357-2725
Subject:
G-protein coupled receptors,   etc   ; animal models; cell membranes; cell polarity; epithelium; gene expression; knockout mutants; mice; signal transduction;     Show all 9 Subjects
Abstract:
... Planar cell polarity (PCP) is defined as the coordinated alignment of cell polarity across the tissue plane, which is important for the integration of cells into tissues. One of the best examples of PCP is in the cochlear epithelium. Several core PCP proteins have been identified to play important roles in PCP regulation, in which these proteins form complexes and associate with the cell membrane ...
DOI:
10.1016/j.biocel.2016.02.011

5. Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway

Author:
Yin, Jia; Li, Haiying; Meng, Chengjie; Chen, Dongdong; Chen, Zhouqing; Wang, Yibin; Wang, Zhong; Chen, Gang
Source:
The international journal of biochemistry & cell biology 2016 v.75 pp. 11-22
ISSN:
1357-2725
Subject:
G-protein coupled receptors,   etc   ; IKappaB kinase; Western blotting; animal models; anti-inflammatory activity; apoptosis; body weight; brain; central nervous system diseases; chemokine CCL2; diet; edema; fish; gel electrophoresis; hemorrhage; inducible nitric oxide synthase; inflammation; mitogen-activated protein kinase; neurons; omega-3 fatty acids; patients; phosphorylation; precipitin tests; prostaglandin synthase; protective effect; rats; signal transduction; small interfering RNA; staining; transcription factor NF-kappa B; transforming growth factors; water content;     Show all 32 Subjects
Abstract:
... Omega-3 fatty acids have been reported to improve neuron functions during aging and in patients affected by mild cognitive impairment, and mediate potent anti-inflammatory via G protein-coupled receptor 120 (GPR120) signal pathway. Neuron dysfunction and inflammatory response also contributed to the progression of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). This study was to ex ...
DOI:
10.1016/j.biocel.2016.03.008