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- Hasan, Shakir; Sebo, Peter; Osicka, Radim
- TheFEBS journal 2018 v.285 no.23 pp. 4343-4358
- animal models; bacterial infections; biomedical research; epithelial cells; gas exchange; host specificity; host-pathogen relationships; lungs; mammals; microorganisms; pathogens; respiratory mucosa
- ... Mammalian lungs are organs exhibiting the cellular and spatial complexity required for gas exchange to support life. The respiratory epithelium internally lining the airways is susceptible to infections due to constant exposure to inhaled microbes. Biomedical research into respiratory bacterial infections in humans has been mostly carried out using small mammalian animal models or two‐dimensional, ...
- Shaul, Merav E.; Fridlender, Zvi G.
- TheFEBS journal 2018 v.285 no.23 pp. 4316-4342
- animal models; humans; immunotherapy; neoplasms; neutrophils; patients; prognosis
- ... In recent years, the role of neutrophils in cancer biology has been a matter of increasing interest. Many patients with advanced cancer show high levels of neutrophilia, tumor neutrophils are connected to dismal prognosis, and the neutrophil‐to‐lymphocyte ratio has been introduced as a significant prognostic factor for survival in many types of cancer. Neutrophils constitute an important portion o ...