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- Flores, J.M., et al. Show all 8 Authors
- Theriogenology 2010 v.73 no.8 pp. 1088-1095
- follicular development; gonadotropins; dose response; leptin; therapeutics; biochemical mechanisms; female fertility; fertilization (reproduction); hormonal regulation; mice; animal models; obesity; noninsulin-dependent diabetes mellitus; ovulation; corpus luteum
- ... The goal of the current was to elucidate if treatment with gonadotrophins and leptin can circumvent infertility in obese mice and to establish whether reproductive effects of leptin are influenced at the hypothalamus-hypophysis or ovarian level by using a leptin deficient mouse model of obesity/type 2 diabetes (ob/ob) treated with leptin. The ovulatory response and the fertilization success were c ...