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- Wen, Xia; Baker, Angela A.; Klaassen, Curtis D.; Corton, J. Christopher; Richardson, Jason R.; Aleksunes, Lauren M.
- Toxicology 2019 v.416 pp. 15-22
- at-risk population; drugs; enzymes; excretion; gene expression regulation; hyperlipidemia; lipids; liver; males; messenger RNA; metabolism; mice; perfluorooctanoic acid; receptors; toxic substances
- ... Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with dyslipidemia in exposed populations. In liver, PFOA can activate nuclear receptors such as PPARα, and alter the metabolism and excretion ...
- PubMed Central:
- Cherif, Boutheina; Triki, Hana; Sahnoun, Sana; Hamden, Khaled; Sallemi, Afifa; Charfi, Slim; Lassoued, Saloua
- Toxicology 2019 v.416 pp. 44-53
- B-cell lymphoma; apoptosis; blood serum; catalase; drugs; enzyme activity; gentamicin; histopathology; imipenem; immunohistochemistry; interleukin-1beta; lipid peroxidation; male fertility; males; moieties; oxidative stress; rats; seminiferous tubules; sperm motility; spermatogenesis; spermatozoa; superoxide dismutase; testosterone; toxicity
- ... Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections. Our goal is to investigate toxicity induced in male rat reproductive systems following exposure to this drug (15, 50 or 100 mg/kg) compared to gentamicin (50 mg/kg) treatment.Effects of imipenem on reproductive organ weights, histoarchitecture, sperm parameters, and oxid ...