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- Wen, Xia; Baker, Angela A.; Klaassen, Curtis D.; Corton, J. Christopher; Richardson, Jason R.; Aleksunes, Lauren M.
- Toxicology 2019 v.416 pp. 15-22
- at-risk population; drugs; enzymes; excretion; gene expression regulation; hyperlipidemia; lipids; liver; males; messenger RNA; metabolism; mice; perfluorooctanoic acid; receptors; toxic substances
- ... Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with dyslipidemia in exposed populations. In liver, PFOA can activate nuclear receptors such as PPARα, and alter the metabolism and excretion ...
- PubMed Central:
- Rebleanu, Daniela; Gaidau, Carmen; Voicu, Geanina; Constantinescu, Cristina Ana; Mansilla Sánchez, Catalina; Rojas, Teresa Cristina; Carvalho, Sandra; Calin, Manuela
- Toxicology 2019 v.416 pp. 30-43
- apoptosis; chemokine CXCL1; cytoskeleton; cytotoxicity; electrochemistry; enzymes; epithelial cells; epithelium; granulocyte-macrophage colony-stimulating factor; human health; humans; industry; inflammation; keratinocytes; leather; lungs; monocytes; nanoparticles; necrosis; neutrophils; nitrogen; photocatalysis; reactive oxygen species; risk; signal transduction; silver; titanium dioxide
- ... The potential human health risks following the exposure to inorganic nanoparticles (NPs) is a very important issue for their application in leather finishing industry. The aim of our study was to investigate the cytotoxic effect of silver (Ag)/titanium dioxide (TiO2) NPs on human cells. Photocatalytic NPs were prepared by electrochemical deposition of Ag on the surface of TiO2 and nitrogen (N)-TiO ...