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You searched for: Journal Toxicology Remove constraint Journal: Toxicology Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.425 Remove constraint Source: 2019 v.425
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1. Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ

Author:
Yang, Bobo; Yin, Changsheng; Zhou, Yun; Wang, Qiang; Jiang, Yuanyue; Bai, Yu; Qian, Hai; Xing, Guangwei; Wang, Suhua; Li, Fang; Feng, Yun; Zhang, Yubin; Cai, Jiyang; Aschner, Michael; Lu, Rongzhu
Source:
Toxicology 2019 v.425 pp. 152248
ISSN:
0300-483X
Subject:
NADP (coenzyme); antioxidant activity; astrocytes; catalase; cell death; curcumin; cytotoxicity; dose response; glutathione; heme oxygenase (biliverdin-producing); humans; lactate dehydrogenase; methylmercury compounds; neuroprotective effect; neurotoxicity; oxidative stress; polyphenols; protein kinase C; quinones; rats; reactive oxygen species; rhizomes; small interfering RNA; turmeric
Abstract:
... Methylmercury (MeHg) is a ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. Curcumin, a polyphenol obtained from the rhizome of turmeric, has well-known antioxidant functions. Here, we evaluated curcumin’s efficacy in mitigating MeHg-induced cytotoxicity and further investigated the underlying mechanism of this neuroprotection in primary rat ...
DOI:
10.1016/j.tox.2019.152248

2. Hormesis: The dose response for the 21st century: The future has arrived

Author:
Agathokleous, Evgenios; Calabrese, Edward J.
Source:
Toxicology 2019 v.425 pp. 152249
ISSN:
0300-483X
Subject:
hormesis; models; toxicology
Abstract:
... Dose-response is the backbone of toxicology, and one of the most debated scientific issues over the 20th century. It was in the last century that the scientific community applauded the discovery of the proportionality rule, so called linear non-threshold dose-response relationship. It was also in the same century that all the regulatory standards were framed around threshold and linear non-thresho ...
DOI:
10.1016/j.tox.2019.152249

3. Melatonin protects against Fenoxaprop-ethyl exposure-induced meiotic defects in mouse oocytes

Author:
He, Ya-Ting; Wang, Wei; Shen, Wei; Sun, Qing-Yuan; Yin, Shen
Source:
Toxicology 2019 v.425 pp. 152241
ISSN:
0300-483X
Subject:
actin; apoptosis; binding capacity; coculture; cytoskeleton; extrusion; fluorescent antibody technique; herbicides; histones; meiosis; melatonin; methylation; mice; models; oocytes; oxidative stress; phenotype; pineal body; protective effect; spermatozoa; tubulin
Abstract:
... Prolonged exposure of Fenoxaprop-ethyl (FE), a post-emergence herbicide, can cause serious damage to animals through food chain. Melatonin is synthesized by the pineal gland in mammals and believed to protect cells from oxidative stress damage. In this study, we aimed to investigate the effects of FE on mouse oocyte meiosis maturation and the protective roles of melatonin on FE-exposed oocytes by ...
DOI:
10.1016/j.tox.2019.152241

4. Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis

Author:
Chung, Yao-Pang; Yen, Cheng-Chieh; Tang, Feng-Cheng; Lee, Kuan-I; Liu, Shing-Hwa; Wu, Chin-Ching; Hsieh, Shang-Shu; Su, Chin-Chuan; Kuo, Chun-Ying; Chen, Ya-Wen
Source:
Toxicology 2019 v.425 pp. 152245
ISSN:
0300-483X
Subject:
NAD ADP-ribosyltransferase; acetylcysteine; apoptosis; binding proteins; blood-brain barrier; caspase-12; caspase-3; cell membranes; central nervous system; cytotoxicity; endoplasmic reticulum; epidemiological studies; mercury; methylmercury compounds; neurodegenerative diseases; neurons; neurotoxicity; neurotoxins; phosphatidylserines; phosphorylation; protein kinases; reactive oxygen species; small interfering RNA; transcription factors; transfection
Abstract:
... Epidemiological studies have positively linked mercury exposure and neurodegenerative diseases (ND). Methylmercury (MeHg), an organic form of mercury, is a ubiquitous and potent environmental neurotoxicant that easily crosses the blood-brain barrier and causes irreversible injury to the central nervous system (CNS). However, the molecular mechanisms underlying MeHg-induced neurotoxicity remain unc ...
DOI:
10.1016/j.tox.2019.152245

5. Potential attenuation of early-life overfeeding-induced metabolic dysfunction by chronic maternal acetylcholinesterase inhibitor exposure

Author:
Valério Prates, Kelly; Ribeiro, Tatiane Aparecida; Pavanello, Audrei; Jacinto Saavedra, Lucas Paulo; Moreira, Veridiana Mota; da Silva Silveira, Sandra; Martins, Isabela Peixoto; Francisco, Flávio Andrade; Ferreira Junior, Marcos Divino; Alves, Vander Silva; Tófolo, Laize Peron; Previate, Carina; da Silva Franco, Claudinéia Conationi; Gomes, Rodrigo Mello; Palma-Rigo, Kesia; Malta, Ananda; de Freitas Mathias, Paulo Cezar
Source:
Toxicology 2019 v.425 pp. 152250
ISSN:
0300-483X
Subject:
acetylcholinesterase; adiposity; adulthood; cholinesterase; enzyme inhibitors; glucose; homeostasis; hyperplasia; insulin; insulin resistance; islets of Langerhans; metabolism; milk; muscarine receptors; nests; noninsulin-dependent diabetes mellitus; organophosphorus compounds; overfeeding; phenotype; pollution; pregnancy; pups; rats; risk
Abstract:
... Evidence suggests that low concentration perinatal exposure to environmental contaminants, such as organophosphate (OP) is associated with later life insulin resistance and type 2 diabetes. The aim of this work was to investigate whether chronic maternal OP exposure exacerbates metabolic dysfunctions in early-overfed rats. During pregnancy and lactational periods, dams received OP by gavage. To in ...
DOI:
10.1016/j.tox.2019.152250

6. Pregnancy exposure to carbon black nanoparticles exacerbates bleomycin-induced lung fibrosis in offspring via disrupting LKB1-AMPK-ULK1 axis-mediated autophagy

Author:
Zhang, Longbin; Cheng, Shuqun; Jiang, Xuejun; Zhang, Jun; Meng, Pan; Tang, Qianghu; Qin, Xia; Wang, Bin; Chen, Chengzhi; Zou, Zhen
Source:
Toxicology 2019 v.425 pp. 152244
ISSN:
0300-483X
Subject:
autophagy; collagen; epidemiological studies; fibrosis; genotoxicity; inflammation; intranasal administration; lungs; nanoparticles; oxidative stress; pregnancy; progeny; risk; soot
Abstract:
... Accumulating evidence shows that carbon black nanoparticles (CBNPs) (one of the most used nanoparticles) can induce toxicity via induction of inflammation, oxidative stress and genotoxicity in vitro and in vivo, and epidemiological studies have indicated that the possible correlation between maternal immune activation and risk of developing neuropsychiatric disorder in the offspring. However, whet ...
DOI:
10.1016/j.tox.2019.152244

7. Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells

Author:
Jiang, Chunteng; Jiang, Liping; Li, Qiannan; Liu, Xiaofang; Zhang, Tianjiao; Yang, Guang; Zhang, Cong; Wang, Ningning; Sun, Xiance; Jiang, Lijie
Source:
Toxicology 2019 v.425 pp. 152238
ISSN:
0300-483X
Subject:
apoptosis; autophagy; cardiotoxicity; caspase-3; caspase-9; cathepsin D; cytochrome c; doxorubicin; hematologic diseases; human umbilical vein endothelial cells; membrane permeability; membrane potential; mitochondria; neoplasms; pathogenesis; quinine
Abstract:
... The cardiotoxicity of doxorubicin (DOX) limits its clinical use in the treatment of a variety of solid tumors and malignant hematologic disease. However, the mechanism by which it causes cardiotoxicity is not fully understood. Apoptosis has been regarded as one of mechanisms underlying the cardiotoxic effects of DOX. In our study, we found that treatment of human umbilical vein endothelial cells ( ...
DOI:
10.1016/j.tox.2019.152238

8. Tributyltin exposure disturbs hepatic glucose metabolism in male mice

Author:
Xu, Jing; Ou, Kunlin; Chen, Chuqiao; Li, Binshui; Guo, Jiaojiao; Zuo, Zhenghong; Wang, Chonggang
Source:
Toxicology 2019 v.425 pp. 152242
ISSN:
0300-483X
Subject:
animal models; blood glucose; blood serum; carboxy-lyases; diabetes mellitus; fasting; gene expression regulation; genes; glucagon; glucagon receptors; gluconeogenesis; glucose; glucose-6-phosphatase; glycogen; insulin; insulin resistance; islets of Langerhans; liver; males; mice; protein synthesis; risk; toxicity; transcription (genetics); tributyltin
Abstract:
... Some previous studies showed that organotin compounds induced diabetes in animal models. The underlying mechanisms should be further revealed. In this study, male KM mice were exposed to tributyltin (TBT) at 0.5, 5 and 50 μg/kg once every three days for 45 days. The TBT-treated mice exhibited an elevation of fasting blood glucose level and glucose intolerance. The fasting serum insulin levels were ...
DOI:
10.1016/j.tox.2019.152242