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- Bouitbir, Jamal; Alshaikhali, Abdallah; Panajatovic, Miljenko V.; Abegg, Vanessa F.; Paech, Franziska; Krähenbühl, Stephan
- Toxicology 2019 v.426 pp. 152281
- DNA fragmentation; adenosine triphosphate; apoptosis; cardiomyocytes; cardiotoxicity; caspase-3; creatine kinase; cytotoxicity; electron microscopy; electron transport chain; enzyme activity; galactose; glucose; glycolysis; hydrogen peroxide; membrane potential; mice; mitochondria; mitochondrial membrane; oxidative stress; rats; troponin I
- ... Sunitinib is cardiotoxic, but the mechanisms are not entirely clear. We aimed to enlarge our knowledge about the role of mitochondria in cardiac toxicity of sunitinib in vitro and in vivo. For this reason, we studied the toxicity of sunitinib on cardiac H9c2 cells exposed for 24 h, permeabilized rat cardiac fibers exposed for 15 min and in mice treated orally with sunitinib for 2 weeks (7.5 mg/kg/ ...