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- Wu, Chia-Yen; Tsai, Yi-Lin; Hsieh, Chung-Pin; Wang, Tsui Chin; Chan, Ming-Huan; Chen, Hwei-Hsien
- Toxicology 2018 v.408 pp. 39-45
- acetylcysteine, etc ; antagonists; antiporters; ataxia (disorder); brain; breathing; cognition; humans; males; memory disorders; mice; poisoning; social behavior; solvents; toluene; Show all 15 Subjects
- ... Toluene, a commonly used organic solvent, produces a variety of behavioral disturbances in both humans and animals comparable to noncompetitive N-methyl-D-aspartate receptor (NMDARs) antagonists, such as phencyclidine (PCP). N-acetylcysteine (NAC) is capable of reversing the psychotomimetic effects of PCP via activation of cystine-glutamate antiporters (xCT). The present study examined whether NAC ...