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- Liu, Kexin, et al. Show all 8 Authors
- Toxicology 2018 v.408 pp. 70-79
- biochemical pathways; birth weight; blood serum; developmental toxicity; drugs; fetus; human cell lines; hyperthyroidism; insulin-like growth factor I; liver; mice; non-specific serine/threonine protein kinase; pregnant women; progeny; protein content; signal transduction; therapeutics
- ... Anti-thyroid drugs (ATDs) therapy is necessary for pregnant women with hyperthyroidism. However, there is a lack of studies on developmental toxicity of ATDs. In this study, we observed the developmental toxicity of fetal liver induced by prenatal methimazole exposure (PME) in mice, and explored the potential mechanism. Pregnant Kunming mice were administered intragastrically with 4.5 or 18 mg/kg· ...