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You searched for: Author "Liu, Kexin" Remove constraint Author: "Liu, Kexin" Journal Toxicology Remove constraint Journal: Toxicology Publication Year 2018 Remove constraint Publication Year: 2018
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1. Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice

Author:
Liu, Kexin,   et al.   ; Wang, Guihua; He, Bo; Hu, Wen; Gong, Xiaohan; Kou, Hao; Guo, Yu; Wang, Hui;     Show all 8 Authors
Source:
Toxicology 2018 v.408 pp. 70-79
ISSN:
0300-483X
Subject:
biochemical pathways; birth weight; blood serum; developmental toxicity; drugs; fetus; human cell lines; hyperthyroidism; insulin-like growth factor I; liver; mice; non-specific serine/threonine protein kinase; pregnant women; progeny; protein content; signal transduction; therapeutics
Abstract:
... Anti-thyroid drugs (ATDs) therapy is necessary for pregnant women with hyperthyroidism. However, there is a lack of studies on developmental toxicity of ATDs. In this study, we observed the developmental toxicity of fetal liver induced by prenatal methimazole exposure (PME) in mice, and explored the potential mechanism. Pregnant Kunming mice were administered intragastrically with 4.5 or 18 mg/kg· ...
DOI:
10.1016/j.tox.2018.07.004