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- Slotkin, Theodore A.; Skavicus, Samantha; Card, Jennifer; Levin, Edward D.; Seidler, Frederic J.
- Toxicology 2015 v.333 pp. 63-75
- acetylcysteine, etc ; DNA; adverse effects; antioxidants; ascorbic acid; cell growth; cell viability; choline; dopamine; folic acid; metabolism; nicotine; oxidative stress; phenotype; smoking (habit); synergism; vitamin B12; vitamin E; Show all 18 Subjects
- ... Tobacco smoke exposure is associated with neurodevelopmental disorders. We used neuronotypic PC12 cells to evaluate the mechanisms by which tobacco smoke extract (TSE) affects neurodifferentiation. In undifferentiated cells, TSE impaired DNA synthesis and cell numbers to a much greater extent than nicotine alone; TSE also impaired cell viability to a small extent. In differentiating cells, TSE enh ...
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