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- Wen, Xiao; Zhao, Wen-hao; Chen, Lan-zhou; Qu, Wen; Liu, Han-xiao; Yan, Hui-yi; Hou, Li-fang; Ping, Jie
- Toxicology 2019 v.428 pp. 152309
- ABC transporters; T-lymphocytes; animal models; autoimmune diseases; cholesterol; cholesterol homeostasis; females; mice; nicotine; progeny; small interfering RNA; thymocytes; transfection
- ... The recession of regulatory T cells (Tregs) contributes to development of autoimmune disease. Our previous study suggested that prenatal nicotine exposure (PNE) inhibited Tregs frequency in offspring, but the mechanisms are still uncertain. This study aimed to explore the molecular mechanisms of PNE-induced Tregs inhibition from the perspective of cellular cholesterol homeostasis both in vivo and ...