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- Zhao, Sheng; Pan, Lei; Chen, Min; Zhu, Yi-Ping; Han, Bang-Min; Xia, Shu-Jie; Jiang, Jun-Tao
- Toxicology 2019 v.428 pp. 152300
- Western blotting; autophagy; dibutyl phthalate; epithelial cells; gene expression; genes; immunohistochemistry; in vitro studies; males; maternal exposure; neonates; progeny; rats; reactive oxygen species; staining; urethra
- ... Maternal exposure to di-n-butyl phthalate (DBP) induces hypospadias via regulation of autophagy in uroepithelial cells. Here, we use gene express analysis to explore the underlying molecular mechanisms. Pregnant rats received DBP orally at a dose of 750 mg/kg/day during gestational days 14–18. Gene expression analysis showed an increased expression of the hedgehog interacting protein (HhIP) gene. ...
- Yu, Kailun; Zhang, Xiuli; Tan, Xuemei; Ji, Mengmeng; Chen, Yao; Tao, Yuchang; Liu, Manman; Yu, Zengli
- Toxicology 2019 v.428 pp. 152311
- adulthood; adults; adverse effects; apoptosis; blood serum; direct contact; endocrine-disrupting chemicals; estrous cycle; females; follicle-stimulating hormone; follicular development; indirect contact; laboratory animals; luteinizing hormone; messenger RNA; ovarian follicles; pregnancy; progeny; rats; reverse transcriptase polymerase chain reaction; tetrachlorodibenzo-p-dioxin; toxicity
- ... 2,3,7,8-Tetrachlorobenze-p-dioxin (TCDD), one of representive Endocrine Disrupting Chemicals (EDCs), has potential adverse effects on human health. Direct exposure to TCDD has been implicated in ovarian follicles development and functions deficits in adulthood. However, it is rarely reported whether indirect exposure to TCDD can cause similar negative impact on F3. The aim of our study was to eval ...