Jump to Main Content
- Hsieh, Chiu-Lan; Wang, Hui-Er; Tsai, Wan-Jane; Peng, Chiung-Chi; Peng, Robert Y.
- Toxicology 2012 v.291 no.1-3 pp. 32-42
- acetylcysteine, etc ; NADP (coenzyme); abnormal development; apoproteins; ascorbic acid; biosynthesis; chickens; cysteine; dihydrofolate reductase; glutamic acid; glutathione; histone deacetylase; homocysteine; hydrogen peroxide; mechanism of action; models; mortality; muscles; risk; spina bifida; superoxide dismutase; teratogenicity; tetrahydrofolic acid; toxicology; translation (genetics); valproic acid; Show all 26 Subjects
- ... The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tried to alleviate the risk of VPA-teratogenicity. The effect was varying. In order to promote the prev ...
- Mögel, Iljana; Baumann, Sven; Böhme, Alexander; Kohajda, Tibor; von Bergen, Martin; Simon, Jan-Christoph; Lehmann, Irina
- Toxicology 2011 v.289 no.1 pp. 28-37
- acetylcysteine, etc ; adhesives; antioxidants; benzene; epithelial cells; humans; mitogen-activated protein kinase; oxidative stress; paints; prostaglandin synthase; prostaglandins; rubber; secretion; smoking (habit); solvents; styrene; toluene; toxicology; traffic; volatile organic compounds; Show all 20 Subjects
- ... Toluene, benzene and styrene are volatile organic compounds (VOCs) widely distributed in the environment. Tobacco smoke, traffic exposure and solvents used for paints, rubber and adhesives are known sources for these compounds. The aim of the present study was to investigate whether toluene, benzene and styrene can induce inflammatory reactions in lung cells and to characterize possible underlying ...