Jump to Main Content
PubAg
Main content area
Search
« Previous |
1 - 20 of 36
|
Next »
Search Results
- Author:
- Meyer, Lauren; Carter, Steve; Capper, Angela
- Source:
- Toxicon 2015 v.108 pp. 249-256
- ISSN:
- 0041-0101
- Subject:
- Scomberomorus; carnivores; ciguatera; ciguatoxin; detection limit; extraction; high performance liquid chromatography; homogenization; humans; mackerel; mass spectrometry; mixing; phospholipids; silica; toxicity; ultrasonic treatment; Queensland
- Abstract:
- ... Ciguatera fish poisoning is a debilitating human neuro-intoxication caused by consumption of tropical marine organisms, contaminated with bioaccumulated ciguatoxins (CTXs). The growing number of cases coupled with the high toxicity of CTXs makes their reliable detection and quantification of paramount importance. Three commonly occurring ciguatoxins, P-CTX-1, 2 and 3 from five different ciguatoxic ...
- DOI:
- 10.1016/j.toxicon.2015.10.021
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.021
- Author:
- McCarthy, Moira; Bane, Vaishali; García-Altares, María; van Pelt, Frank N.A.M.; Furey, Ambrose; O'Halloran, John
- Source:
- Toxicon 2015 v.108 pp. 202-209
- ISSN:
- 0041-0101
- Subject:
- adsorption; algae; coasts; marine toxins; temporal variation; Ireland
- Abstract:
- ... Active and passive sampling methods were employed over a four-month period, at a site off the South-West coast of Ireland, to characterise the occurrence of cyclic imines in the water column. The marine toxins 13-desmethyl-SPXC, 20-methyl SPXG toxins and pinnatoxin G were detected using active sampling from Diaion HP-20 resin. Seven water depths were sampled to determine stratification of the toxi ...
- DOI:
- 10.1016/j.toxicon.2015.10.007
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.007
- Author:
- Marinho, Aline D.; Morais, Isabel C.O.; Lima, Dânya B.; Jorge, Antônio R.C.; Jorge, Roberta J.B.; Menezes, Ramon R.P.P.B.; Mello, Clarissa P.; Pereira, Gustavo J.S.; Silveira, João A.M.; Toyama, Marcos H.; Orzáez, Mar; Martins, Alice M.C.; Monteiro, Helena S.A.
- Source:
- Toxicon 2015 v.108 pp. 126-133
- ISSN:
- 0041-0101
- Subject:
- Bothrops; apoptosis; caspases; cell viability; cytotoxicity; epithelial cells; flow cytometry; glomerular filtration rate; inhibitory concentration 50; kidneys; membrane potential; mitochondrial membrane; morbidity; mortality; nephrotoxicity; propidium; snake bites; sodium; transportation; venoms
- Abstract:
- ... Snake envenomation (Bothrops genus) is common in tropical countries and acute kidney injury is one of the complications observed in Bothrops snakebite with relevant morbidity and mortality. Here, we showed that Bothropoides pauloensis venom (BpV) decreased cell viability (IC50 of 7.5 μg/mL). Flow cytometry with annexin V and propidium iodide showed that cell death occurred predominantly by apoptos ...
- DOI:
- 10.1016/j.toxicon.2015.09.031
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.031
- Author:
- Buch, Daniela Regina; Souza, Fernanda Nunes; Meissner, Gabriel Otto; Morgon, Adriano Marcelo; Gremski, Luiza Helena; Ferrer, Valéria Pereira; Trevisan-Silva, Dilza; Matsubara, Fernando Hitomi; Boia-Ferreira, Mariana; Sade, Youssef Bacila; Chaves-Moreira, Daniele; Gremski, Waldemiro; Veiga, Silvio Sanches; Chaim, Olga Meiri; Senff-Ribeiro, Andrea
- Source:
- Toxicon 2015 v.108 pp. 154-166
- ISSN:
- 0041-0101
- Subject:
- Loxosceles; accidents; antiserum; blood serum; cross reaction; epitopes; humans; hyaluronoglucosaminidase; immunoassays; metalloproteinases; therapeutics; toxins; venoms; Brazil
- Abstract:
- ... Loxosceles spiders are responsible for serious human envenomations worldwide. The collection of symptoms found in victims after accidents is called loxoscelism and is characterized by two clinical conditions: cutaneous loxoscelism and systemic loxocelism. The only specific treatment is serum therapy, in which an antiserum produced with Loxosceles venom is administered to the victims after spider a ...
- DOI:
- 10.1016/j.toxicon.2015.09.041
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.041
- Author:
- Hatakeyama, Tomomitsu; Higashi, Erika; Nakagawa, Hideyuki
- Source:
- Toxicon 2015 v.108 pp. 46-52
- ISSN:
- 0041-0101
- Subject:
- Echinoidea; Escherichia coli; amino acids; complementary DNA; muscle contraction; nucleotide sequences; phospholipase A2; predators; proteins; reverse transcriptase polymerase chain reaction; sequence homology; signal peptide; smooth muscle; toxicity; transcription (genetics)
- Abstract:
- ... Venomous sea urchins contain various biologically active proteins that are toxic to predators. Contractin A is one such protein contained within the globiferous pedicellariae of the venomous sea urchin Toxopneustes pileolus. This protein exhibits several biological activities, such as smooth muscle contraction and mitogenic activity. N-terminal amino acid residues of Contractin A have been determi ...
- DOI:
- 10.1016/j.toxicon.2015.09.040
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.040
- Author:
- da Silva, Juliana Figueira; Castro-Junior, Célio José; Oliveira, Sara Marchesan; Dalmolin, Gerusa Duarte; Silva, Cássia Regina; Vieira, Luciene Bruno; Diniz, Danuza Montijo; Cordeiro, Marta do Nascimento; Ferreira, Juliano; Souza, Alessandra Hubner; Gomez, Marcus Vinícius
- Source:
- Toxicon 2015 v.108 pp. 53-61
- ISSN:
- 0041-0101
- Subject:
- Phoneutria nigriventer; adverse effects; analgesic effect; calcium channels; cerebrospinal fluid; formalin test; glutamate receptors; glutamic acid; hypersensitivity; ischemia; locomotion; mice; models; morphine; neuroprotective effect; pain; peptides; prototypes; venoms
- Abstract:
- ... Venom-derived peptides constitute a unique source of drug prototypes for the pain management. Many of them can modulate voltage-gated calcium channels that are central in the processing of pain sensation. PhTx3-4 is a peptide isolated from Phoneutria nigriventer venom, which blocks high voltage-activated calcium channels with low specificity, thereby leading to neuroprotection in models of ischemi ...
- DOI:
- 10.1016/j.toxicon.2015.09.043
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.043
- Author:
- D'Suze, Gina; Sandoval, Moisés; Sevcik, Carlos
- Source:
- Toxicon 2015 v.108 pp. 62-72
- ISSN:
- 0041-0101
- Subject:
- Tityus; algorithms; captive animals; environmental factors; gender; quantitative analysis; reversed-phase high performance liquid chromatography; sexual dimorphism; venoms
- Abstract:
- ... A characteristic of venom elution patterns, shared with many other complex systems, is that many their features cannot be properly described with statistical or euclidean concepts. The understanding of such systems became possible with Mandelbrot's fractal analysis. Venom elution patterns were produced using the reversed phase high performance liquid chromatography (HPLC) with 1 mg of venom. One r ...
- DOI:
- 10.1016/j.toxicon.2015.09.034
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.034
- Author:
- Ryan, Nicole M.; Downes, Michael A.; Isbister, Geoffrey K.
- Source:
- Toxicon 2015 v.108 pp. 181-183
- ISSN:
- 0041-0101
- Subject:
- Pseudechis; adrenal cortex hormones; analgesia; antibodies; antihistamines; antiserum; antivenoms; blood serum; females; immune response; immune system; knees; legs; morbidity; muscles; nausea; pain; patients; prednisone; pruritus; snakes
- Abstract:
- ... Serum sickness is a delayed immune reaction in which the immune system responds to a protein in antiserum as a potentially harmful substance and mounts an IgG-mediated antibody response. A 32 year-old female patient had systemic envenoming following a bite by a red-bellied black snake (Pseudechis porphyriacus). She was treated with Tiger snake antivenom and recovered over 24 h and did not develop ...
- DOI:
- 10.1016/j.toxicon.2015.10.012
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.012
- Author:
- Ebrahim, Karim; Shirazi, Farshad H.; Mirakabadi, Abbas Zare; Vatanpour, Hossein
- Source:
- Toxicon 2015 v.108 pp. 134-140
- ISSN:
- 0041-0101
- Subject:
- acridine orange; antineoplastic activity; apoptosis; caspase-3; cathepsins; cell proliferation; chromatography; cisplatin; cytosol; cytotoxicity; cytotoxins; ethidium; flow cytometry; homeostasis; inhibitory concentration 50; necrosis; polypeptides; staining; venoms
- Abstract:
- ... Organs homeostasis is controlled by a dynamic balance between cell proliferation and apoptosis. Failure to induction of apoptosis has been implicated in tumor development. Cytotoxin-I (CTX-I) and cytotoxin-II (CTX-II) are two physiologically active polypeptides found in Caspian cobra venom. Anticancer activity and mechanism of cell death induced by these toxins have been studied. The toxins were p ...
- DOI:
- 10.1016/j.toxicon.2015.09.017
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.017
- Author:
- Sánchez, Andrés; Coto, Jorge; Segura, Álvaro; Vargas, Mariángela; Solano, Gabriela; Herrera, María; Villalta, Mauren; Estrada, Ricardo; Gutiérrez, José María; León, Guillermo
- Source:
- Toxicon 2015 v.108 pp. 80-83
- ISSN:
- 0041-0101
- Subject:
- Bitis arietans; Echis; Naja; antivenoms; geographical variation; neutralization; venoms; Cameroon
- Abstract:
- ... Two antivenoms prepared by using Echis ocellatus, Bitis arietans and Naja nigricollis venoms from different locations in sub-Saharan Africa were compared for their neutralizing ability. Both antivenoms were similarly effective in the neutralization of the venoms of the three species from different locations. However in the case of E. ocellatus venom, antivenom prepared using venom from Nigerian sp ...
- DOI:
- 10.1016/j.toxicon.2015.10.001
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.001
- Author:
- Teles, A.V.F.F.; Fock, R.A.; Górniak, S.L.
- Source:
- Toxicon 2015 v.108 pp. 73-79
- ISSN:
- 0041-0101
- Subject:
- Senna occidentalis; bone marrow; crops; diet; erythrocyte count; hemosiderin; humans; hyperplasia; long term effects; males; poisonous plants; rats; reticulocytes; seeds; spleen; toxicity
- Abstract:
- ... Senna occidentalis (S. occidentalis) is a toxic leguminous plant that contaminates crops and has been shown to be toxic to several animal species. All parts of the plant are toxic, but most of the plant's toxicity is due to its seeds. Despite its toxicity, S. occidentalis is widely used for therapeutic purposes in humans. The aim of the present work was to investigate, for the first time, the effe ...
- DOI:
- 10.1016/j.toxicon.2015.09.042
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.042
- Author:
- Jollivet, V.; Hamel, J.F.; de Haro, L.; Labadie, M.; Sapori, J.M.; Cordier, L.; Villa, A.; Nisse, P.; Puskarczyk, E.; Berthelon, L.; Harry, P.; Boels, D.
- Source:
- Toxicon 2015 v.108 pp. 97-103
- ISSN:
- 0041-0101
- Subject:
- Viperidae; anaphylaxis; death; heparin; immunotherapy; molecular weight; morbidity; neurotoxicity; patients; prospective studies; risk; venoms; France
- Abstract:
- ... Immunotherapy is the gold standard treatment for patients bitten by European vipers in France; it significantly decreases morbidity, frequency and severity of complications and length of stay. A national prospective study was performed by all Poison Control Centers (PCC) to validate the emergency protocol for viper envenomations.This prospective study included all cases of viper bites in France, t ...
- DOI:
- 10.1016/j.toxicon.2015.09.039
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.039
- Author:
- Sanz, Miriam; Dörr, Felipe Augusto; Pinto, Ernani
- Source:
- Toxicon 2015 v.108 pp. 15-18
- ISSN:
- 0041-0101
- Subject:
- Cyanobacteria; mass spectrometry; peptides; toxicity
- Abstract:
- ... High resolution mass spectrometry investigation of an extract of the toxic cyanobacterium Sphaerospermopsis torques-reginae ITEP-024 led to the discovery of four new spumigin congeners. The structures for these peptides were postulated on the basis of accurate mass data and isotopic pattern information of both full scan and product ion spectra. This is the first reported evidence of spumigins on S ...
- DOI:
- 10.1016/j.toxicon.2015.09.019
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.019
- Author:
- Suriyanti, S.N.P.; Usup, Gires
- Source:
- Toxicon 2015 v.108 pp. 257-263
- ISSN:
- 0041-0101
- Subject:
- Nitzschia; brackish water; cage culture; cages; domoic acid; high performance liquid chromatography; phytoplankton; screening; seafoods; toxicity; water salinity; Malaysia
- Abstract:
- ... Screening of the occurrence of potentially toxic diatoms was carried out at two sites of cage cultures in Tebrau Straits, Johor. Phytoplankton samples from Sungai Pendas and Teluk Sengat were collected using a 20 μm mesh plankton net and salinity was recorded in-situ. Nitzschia and Pseudo-nitzschia cells were isolated and established into clonal cultures. All cultures were tested for domoic acid u ...
- DOI:
- 10.1016/j.toxicon.2015.10.017
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.017
- Author:
- Urra, Félix A.; Pulgar, Rodrigo; Gutiérrez, Ricardo; Hodar, Christian; Cambiazo, Verónica; Labra, Antonieta
- Source:
- Toxicon 2015 v.108 pp. 19-31
- ISSN:
- 0041-0101
- Subject:
- Dipsadidae; Elapidae; Viperidae; anticoagulants; genes; humans; metalloproteinases; natriuretic peptides; proteolysis; serine proteinases; signal peptide; snakes; toxins; venoms; Chile
- Abstract:
- ... Philodryas chamissonis is a rear-fanged snake endemic to Chile. Its bite produces mild to moderate symptoms with proteolytic and anti-coagulant effects. Presently, the composition of the venom, as well as, the biochemical and structural characteristics of its toxins, remains unknown. In this study, we cloned and reported the first full-length sequences of five toxin-encoding genes from the venom g ...
- DOI:
- 10.1016/j.toxicon.2015.09.032
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.032
- Author:
- Konoki, Keiichi; Okada, Kayo; Kohama, Mami; Matsuura, Hiroki; Saito, Kaori; Cho, Yuko; Nishitani, Goh; Miyamoto, Tomofumi; Fukuzawa, Seketsu; Tachibana, Kazuo; Yotsu-Yamashita, Mari
- Source:
- Toxicon 2015 v.108 pp. 38-45
- ISSN:
- 0041-0101
- Subject:
- Porifera; amino acid sequences; binding proteins; detection limit; genes; genomics; nylon; okadaic acid; penicillins; production functions; ribosomal DNA; streptomycin
- Abstract:
- ... Okadaic acid (OA) and OA binding protein 2 (OABP2) were previously isolated from the marine sponge Halichondria okadai. Because the amino acid sequence of OABP2 is completely different from that of protein phosphatase 2A, a well-known target of OA, we have been investigating the production and function of OABP2. In the present study, we hypothesized that OABP2 plays a role in the detoxification of ...
- DOI:
- 10.1016/j.toxicon.2015.09.026
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.026
- Author:
- Baldo, C.; Lopes, D.S.; Faquim-Mauro, E.L.; Jacysyn, J.F.; Niland, S.; Eble, J.A.; Clissa, P.B.; Moura-da-Silva, A.M.
- Source:
- Toxicon 2015 v.108 pp. 240-248
- ISSN:
- 0041-0101
- Subject:
- apoptosis; basement membrane; cell culture; collagen; endothelial cells; fibronectins; hemorrhage; hydrolysis; in vivo studies; integrins; ischemia; metalloproteinases; snakes; venoms
- Abstract:
- ... Hemorrhage is one of the most striking effects of bites by viper snakes resulting in fast bleeding and ischemia in affected tissues. Snake venom metalloproteinases (SVMPs) are responsible for hemorrhagic activity, but the mechanisms involved in SVMP-induced hemorrhage are not entirely understood and the study of such mechanisms greatly depends on in vivo experiments. In vivo, hemorrhagic SVMPs acc ...
- DOI:
- 10.1016/j.toxicon.2015.10.016
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.016
- Author:
- Alves, Thiago J.S.; Wanderley-Teixeira, Valéria; Teixeira, Álvaro A.C.; Alves, Luiz C.; Araújo, Breno C.; Barros, Eduardo M.; Cunha, Franklin M.
- Source:
- Toxicon 2015 v.108 pp. 104-107
- ISSN:
- 0041-0101
- Subject:
- Bracon; bites and stings; chitin; epithelium; hosts; paralysis; parasitic wasps; venoms
- Abstract:
- ... It was described the morphology and histological composition of the structures related to production, storage and distribution of Bracon vulgaris venom, a wasp that parasite their hosts after the inoculation of a venom which causes irreversible paralysis. Were found 22 glandular filaments, coated with secretory epithelium associated with a reservoir coated internally by a chitin layer and external ...
- DOI:
- 10.1016/j.toxicon.2015.10.006
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.006
- Author:
- Macrander, Jason; Broe, Michael; Daly, Marymegan
- Source:
- Toxicon 2015 v.108 pp. 184-188
- ISSN:
- 0041-0101
- Subject:
- Anthozoa; genes; transcriptome; venoms
- Abstract:
- ... Using a partial transcriptome of the snakelocks anemone (Anemonia sulcata) we identify toxin gene candidates that were incorrectly assembled into several Trinity components. Our approach recovers hidden diversity found within some toxin gene families that would otherwise go undetected when using Trinity, a widely used program for venom-focused transcriptome reconstructions. Unidentified hidden tra ...
- DOI:
- 10.1016/j.toxicon.2015.09.038
-
http://dx.doi.org/10.1016/j.toxicon.2015.09.038
- Author:
- Fayad, Paul B.; Roy-Lachapelle, Audrey; Duy, Sung Vo; Prévost, Michèle; Sauvé, Sébastien
- Source:
- Toxicon 2015 v.108 pp. 167-175
- ISSN:
- 0041-0101
- Subject:
- World Health Organization; algal blooms; cylindrospermopsin; detection limit; guidelines; lakes; liquid chromatography; microcystin-LR; phenylalanine; solid phase extraction; surface water; system optimization; tandem mass spectrometry; Quebec
- Abstract:
- ... An analytical method based on on-line SPE-LC-HESI-MS/MS has been developed for the detection and quantification of eight selected cyanotoxins in algal bloom waters that include mycrocystins, anatoxin-a and cylindrospermopsin. The injection volume was 2 mL according to the expected concentration of cyanotoxins in matrix. The method provides an analysis time of 7 min per sample, acceptable recovery ...
- DOI:
- 10.1016/j.toxicon.2015.10.010
-
http://dx.doi.org/10.1016/j.toxicon.2015.10.010