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You searched for: Journal Transboundary and emerging diseases Remove constraint Journal: Transboundary and emerging diseases Publication Year 2009 Remove constraint Publication Year: 2009 Source 2009 v.56 no.6-7 Remove constraint Source: 2009 v.56 no.6-7
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1. Antigen Mining to Define Mycobacterium bovis Antigens for the Differential Diagnosis of Vaccinated and Infected Animals: A VLA Perspective

Author:
Vordermeier, M.; Gordon, S.V.; Hewinson, A.R.G.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 240-247
ISSN:
1865-1674
Subject:
Mycobacterium bovis; Mycobacterium tuberculosis; antigens; cattle; genome; nucleotide sequences; prototypes; transcriptomics; vaccine development; vaccines; United Kingdom
Abstract:
... The urgency for new and improved cattle vaccines and diagnostic reagents has been acknowledged by the UK Government, and development of cattle vaccine is a research priority. Significant progress has been made to develop specific antigens that allow the differentiation of bacille Calmette-Guerin (BCG) vaccinated and M. bovis-infected cattle [diagnosis of infected from vaccinated individuals (DIVA) ...
DOI:
10.1111/j.1865-1682.2009.01070.x
PubMed:
19413883

2. Autophagy and the Immune Response to TB

Author:
Harris, J.; Hope, J.C.; Lavelle, E.C.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 248-254
ISSN:
1865-1674
Subject:
antigen presentation; antigen-presenting cells; cytokines; immune response; metabolism; microorganisms; organelles
Abstract:
... Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen-presenting cells to mycobacteria, inc ...
DOI:
10.1111/j.1865-1682.2009.01069.x
PubMed:
19389082

3. Co-Infection of Cattle with Fasciola hepatica and Mycobacterium bovis- Immunological Consequences

Author:
Flynn, R.J.; Mulcahy, G.; Welsh, M.; Cassidy, J.P.; Corbett, D.; Milligan, C.; Andersen, P.; Strain, S.; McNair, J.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 269-274
ISSN:
1865-1674
Subject:
Fasciola hepatica; Mycobacterium; bovine tuberculosis; cattle; delayed hypersensitivity; disease course; disease diagnosis; immune response; liver flukes
Abstract:
... Fasciola hepatica, the liver fluke, is a common parasite of cattle in much of the world. Previously, we have shown that cattle infected with F. hepatica have altered responsiveness (delayed type hypersensitivity reaction and cytokine responses) to M. bovis BCG infection. We hypothesized that co-infection with F. hepatica would, likewise, alter the immune response of cattle to virulent M. bovis inf ...
DOI:
10.1111/j.1865-1682.2009.01075.x
PubMed:
19575746

4. Evaluation of Granulysin and Perforin as Candidate Biomarkers for Protection Following Vaccination with Mycobacterium bovis BCG or M. bovisΔRD1

Author:
Capinos Scherer, Charles F.; Endsley, Janice J.; de Aguiar, Juliana B.; Jacobs Jr, William R.; Larsen, Michelle H.; Palmer, Mitchell.V.; Nonnecke, Brian J.; Ray Waters, W.; Mark Estes, D.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 228-239
ISSN:
1865-1674
Subject:
Mycobacterium bovis BCG; T-lymphocytes; antimicrobial proteins; biomarkers; cattle; flow cytometry; gene expression; secretion; tuberculosis; vaccination; vaccine development; vaccines
Abstract:
... The development of improved vaccines against tuberculosis (TB) is directly linked to the investigation of new and better correlates of protection after vaccination against TB. Cloning and characterization of bovine homologues of the antimicrobial protein granulysin (Bo-lysin) and perforin by our group could be used as potential biomarkers for TB vaccination efficacy. In the present study, we exami ...
DOI:
10.1111/j.1865-1682.2008.01058.x

5. Gene Expression Profiling of the Host Response to Mycobacterium bovis Infection in Cattle

Author:
MacHugh, D.E.; Gormley, E.; Park, S.D.E.; Browne, J.A.; Taraktsoglou, M.; O'Farrelly, C.; Meade, K.G.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 204-214
ISSN:
1865-1674
Subject:
European Union; Mycobacterium bovis; biomarkers; bovine tuberculosis; cattle; gene expression; gene interaction; hosts; human health; immune response; microarray technology; monitoring; new technology; transcription (genetics); Ireland; United Kingdom
Abstract:
... Bovine tuberculosis (BTB), caused by Mycobacterium bovis, continues to pose a threat to livestock worldwide and, as a zoonotic infection, also has serious implications for human health. The implementation of comprehensive surveillance programmes to detect BTB has been successful in reducing the incidence of infection in many countries, yet BTB has remained recalcitrant to eradication in several EU ...
DOI:
10.1111/j.1865-1682.2009.01082.x
PubMed:
19486308

6. Lipids of Pathogenic Mycobacteria: Contributions to Virulence and Host Immune Suppression

Author:
Guenin-Macé, L.; Siméone, R.; Demangel, C.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 255-268
ISSN:
1865-1674
Subject:
Mycobacterium tuberculosis; cell walls; chemical structure; disinfectants; hosts; lipids; monitoring; receptors; virulence
Abstract:
... Mycobacteria are characterized by a complex cell wall, the lipid nature of which confers to the bacilli resistance to drying, acid or alkaline conditions, and to chemical disinfectants and therapeutic agents. Pathogenic species, such as Mycobacterium tuberculosis, M. leprae and M. ulcerans, have evolved various strategies to establish residence in their hosts and provoke long-term infections. Ther ...
DOI:
10.1111/j.1865-1682.2009.01072.x
PubMed:
19486312

7. Review of the Diagnosis and Study of Tuberculosis in Non-Bovine Wildlife Species Using Immunological Methods

Author:
Chambers, M.A.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 215-227
ISSN:
1865-1674
Subject:
Mycobacterium bovis; biodiversity; bovine tuberculosis; diagnostic sensitivity; livestock; wildlife
Abstract:
... The infection of a variety of free-ranging wildlife species with Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), can cause problems for biodiversity and species conservation. In some notable cases, particular species act as a reservoir of infection that can spill over into domestic livestock with economic and zoonotic consequences. Immunological methods for the detection of T ...
DOI:
10.1111/j.1865-1682.2009.01076.x
PubMed:
19486311

8. Study of Microbiological and Molecular Typing Aspects of Paratuberculosis in Sheep and Goats in Northern Greece

Author:
Dimareli-Malli, Z.; Stevenson, K.; Sarris, K.; Sossidou, K.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 285-290
ISSN:
1865-1674
Subject:
Mycobacterium avium subsp. paratuberculosis; digestive system diseases; feces; goats; intestines; lymph nodes; nutrient intake; paratuberculosis; pulsed-field gel electrophoresis; restriction fragment length polymorphism; sheep; Greece
Abstract:
... Mycobacterium avium subsp. paratuberculosis, an acid-fast bacterium is the agent of Johne's disease, an intestinal disease that causes poor nutrient intake in ruminants. During the period 1987-2003, 322 of 777 (41.4%) goat herds and 97 of 458 (21.1%) sheep flocks were found to be infected with M.a.paratuberculosis in Northern Greece. From goats, mycobacteria were isolated from 238 of 652 (36.5%) o ...
DOI:
10.1111/j.1865-1682.2009.01071.x
PubMed:
19413882

9. WC1⁺γδ T Cells Indirectly Regulate Chemokine Production During Mycobacterium bovis Infection in SCID-bo Mice

Author:
Alvarez, A.J.; Endsley, J.J.; Werling, D.; Mark Estes, D.
Source:
Transboundary and emerging diseases 2009 v.56 no.6-7 pp. 275-284
ISSN:
1865-1674
Subject:
Mycobacterium bovis; T-lymphocytes; cattle; chemokines; chemotaxis; cytotoxicity; enzyme-linked immunosorbent assay; inflammation; liver; mice; monoclonal antibodies; mycobacterial diseases; spleen; splenocytes
Abstract:
... Previous studies have suggested an important role for WC1⁺γδ T cells in the regulation of mycobacterial-induced inflammation in the spleen and liver of heterochimeric SCID-bovine (SCID-bo) mice. To examine the role of these cells, we investigated the levels of selected chemokines and IL12-p70 post-infection in reconstituted SCID-bo mice. Mice were treated with a monoclonal antibody specific for bo ...
DOI:
10.1111/j.1865-1682.2009.01081.x