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- Osorio, Fernando G.; Obaya, Álvaro J.; López-Otín, Carlos; Freije, José M. P.
- Transgenic research 2009 v.18 no.1 pp. 7-15
- elderly; longevity; phenotype; mutation; therapeutics; mice; stem cells; genes; animal models; nuclear membrane
- ... Ageing research benefits from the study of accelerated ageing syndromes such as Hutchinson-Gilford progeria syndrome (HGPS), characterized by the early appearance of symptoms normally associated with advanced age. Most HGPS cases are caused by a mutation in the gene LMNA, which leads to the synthesis of a truncated precursor of lamin A known as progerin that lacks the target sequence for the metal ...
- Hüsemann, Yves; Klein, Christoph A.
- Transgenic research 2009 v.18 no.1 pp. 1-5
- animal models; gene targeting; humans; metastasis; mice; neoplasms; patients; xenotransplantation
- ... Human metastasis has been modeled mostly by xenotransplantation of cell lines in immunodeficient mice. Since this approach frequently uses cell lines derived from metastases, it ignores the significant role of cellular selection processes before and during metastatic progression and, in fact, models metastasis from metastasis and not metastasis from primary tumours. While the importance of the lat ...