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- Hirabayashi, Masumi; Yoshizawa, Yusuke; Kato, Megumi; Tsuchiya, Takashi; Nagao, Shizuko; Hochi, Shinichi
- Transgenic research 2009 v.18 no.1 pp. 135-141
- actin; atrophy; busulfan; chickens; fluorescence; green fluorescent protein; humans; metallothionein; parturition; progeny; rats; seminiferous tubules; spermatids; spermatogenesis; spermatogonia; spermatozoa; stem cells; transgenes
- ... The spermatogonial transplantation system was applied to evaluate stem cell kinetics and niche quality and to produce gene-modified animals using the stem cells after homologous recombination-based selection. This study was designed to determine whether the transplanted spermatogonia were able to proliferate and differentiate in male rats expressing the c-myc transgene under control of the human m ...
- Markoullis, Kyriaki; Bulian, Diana; Hölzlwimmer, Gabriele; Quintanilla-Martinez, Leticia; Heiliger, Katrin-Janine; Zitzelsberger, Horst; Scherb, Hagen; Mysliwietz, Josef; Uphoff, Cord C.; Drexler, Hans G.; Adler, Thure; Busch, Dirk H.; Schmidt, Jörg; Mahabir, Esther
- Transgenic research 2009 v.18 no.1 pp. 71-87
- Mycoplasma; T-lymphocytes; antibodies; blastocyst; cachexia; chimerism; embryo transfer; embryonic stem cells; flow cytometry; germ cells; immunoglobulin M; mice; nose; postnatal development; progeny; pups; viability
- ... Murine embryonic stem cells (mESCs) inoculated at passage P13 with the mycoplasma species M. hominis, M. fermentans and M. orale and cultured over 20 passages showed reduced growth rate and viability (P < 0.0001) compared to control mESCs. Spectral karyotypic analysis of mycoplasma-infected mESCs showed a number of non-clonal chromosomal aberrations which increased with the duration of infection. ...