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- Matsumoto, Yasunobu; Suzuki, Seiko; Nozoye, Tomoko; Yamakawa, Takashi; Takashima, Yasuhiro; Arakawa, Takeshi; Tsuji, Naotoshi; Takaiwa, Fumio; Hayashi, Yoshihiro
- Transgenic research 2009 v.18 no.2 pp. 185-192
- rice; adjuvants; grain crops; blood serum; antigens; oral administration; Oryza sativa; antibodies; recombinant fusion proteins; Ascaris suum; corn; secondary immunization; transgenic plants; mice; vaccines; endosperm; immune response; cholera toxin; eggs
- ... Cereal crops such as maize and rice are considered attractive for vaccine production and oral delivery. Here, we evaluated the rice Oryza sativa for production of As16--an antigen protective against the roundworm Ascaris suum. The antigen was produced as a chimeric protein fused with cholera toxin B subunit (CTB), and its expression level in the endosperm reached 50 μg/g seed. Feeding the transgen ...