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You searched for: Journal Trends in analytical chemistry Remove constraint Journal: Trends in analytical chemistry Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 Remove constraint Source: 2019
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1. Current trends in QuEChERS method. A versatile procedure for food, environmental and biological analysis TrAC- Special Issue “Green Extraction Techniques”

Author:
Santana-Mayor, Álvaro; Socas-Rodríguez, Bárbara; Herrera-Herrera, Antonio V.; Rodríguez-Delgado, Miguel Ángel
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
fruits; green chemistry; pesticides; vegetables
Abstract:
... QuEChERS (quick, easy, cheap, effective, rugged, and safe) method was initially developed by Anastassiades and coworkers as an interesting alternative based on the main principles of the Green Chemistry to the determination of pesticides in fruit and vegetables. However, the great versatility of the procedure has allowed its application in other types of matrices and analytes with excellent result ...
DOI:
10.1016/j.trac.2019.04.018

2. Engineering Microfluidic chip for Circulating Tumor Cells: From Enrichment, Release to Single Cell Analysis

Author:
Yu, Xu; Wu, Na; Chen, Feng; Wei, Jing; Zhao, Yongxi
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
drug resistance; engineering; genomics; monitoring; neoplasm cells; neoplasms; organ-on-a-chip; proteomics; therapeutics
Abstract:
... Circulating tumor cells (CTCs) contain relatively complete clinical information of the original tumors that could be used for cancer diagnosis, therapy monitoring and drug resistance evaluation. The microfluidic chip is a promising tool for the low abundance of CTC enrichment, controllable release and downstream analysis. It will help to unlock the innate powers of the CTCs for establishment of bi ...
DOI:
10.1016/j.trac.2019.03.027

3. Microfluidic analysis of heterotypic cellular interactions: a review of techniques and applications

Author:
Sakthivel, Kabilan; O’Brien, Allen; Kim, Keekyoung; Hoorfar, Mina
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
cell communication; coculture; disease models; droplets; drugs; engineering; guidelines; screening
Abstract:
... Analyzing heterotypic cellular communications is essential to understand various physiological and pathological mechanisms. Although static, 2-dimensional in vitro cell monoculture models allow a high degree of experimental control, they poorly approximate in vivo conditions due to the lack of heterotypic cellular interactions. Co-culture systems permit such interactions and recently, microfluidic ...
DOI:
10.1016/j.trac.2019.03.026

4. Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues

Author:
Pan, Yitao; Wang, Jinghua; Yeung, Leo W.Y.; Wei, Si; Dai, Jiayin
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
gas chromatography; mass spectrometry; perfluorocarbons; toxicity
Abstract:
... The increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine ...
DOI:
10.1016/j.trac.2019.04.013

5. Current analytical methodologies and gaps for per- and polyfluoroalkyl substances determination in the marine environment

Author:
Feng, Hongru; Ruan, Yuefei; Zhang, Kai; Lam, Paul K.S.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
adverse effects; environmental fate; fluorine; marine environment; oceans; organofluorine compounds; risk assessment
Abstract:
... Per- and polyfluoroalkyl substances (PFASs) have attracted worldwide concern. As the phase-out and substitution of PFASs continue to progress, substantial research efforts are being invested into researching the distribution and potential adverse effects of these substances. Oceans are the main final global sinks for most PFASs, and the marine environment plays a key role in their global transport ...
DOI:
10.1016/j.trac.2018.12.026

6. Global interlaboratory assessments of perfluoroalkyl substances under the Stockholm Convention on persistent organic pollutants

Author:
Fiedler, H.; van der Veen, I.; de Boer, J.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
air; breast milk; fish; geographical distribution; humans; interleukin-2; monitoring; perfluorocarbons; perfluorooctane sulfonic acid; persistent organic pollutants; sediments; statistical models; Africa; Asia; Caribbean; Europe; Western European region
Abstract:
... The Global Monitoring Plan (GMP) according to article 16 of the Stockholm Convention on Persistent Organic Pollutants (POPs) requires that POP laboratories must be capable – at any time – to analyse samples for POPs within a variation of ±25%. Based on this target error of 25%, a statistical model using z-scores was applied to assess the performance of analytical laboratories for POPs and a number ...
DOI:
10.1016/j.trac.2019.03.023

7. High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples

Author:
Liu, Yanna; D'Agostino, Lisa A.; Qu, Guangbo; Jiang, Guibin; Martin, Jonathan W.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
fluorine; hazard characterization; humans; mass spectrometry; monitoring; pollution
Abstract:
... Widespread environmental contamination of legacy long-chain poly- and per-fluoroalkyl substances (PFASs) has triggered chemical regulatory action and a global transitioning to alternative PFASs. More than 5000 PFASs are now recognized on various lists, but few have been monitored despite ample evidence of unidentified organic fluorine in human and environmental samples. Nevertheless, our review of ...
DOI:
10.1016/j.trac.2019.02.021

8. Is the phase-out of long-chain PFASs measurable as fingerprint in a defined area? Comparison of global PFAS concentrations and a monitoring study performed in Hesse, Germany from 2014 to 2018

Author:
Janousek, Raphael M.; Mayer, Jens; Knepper, Thomas P.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
analytical chemistry; aquatic environment; monitoring; perfluorocarbons; surface water; Germany
Abstract:
... Perfluoroalkyl and polyfluoroalkyl substances (PFASs) represent a group of anthropogenic chemicals that were produced since the 1950s, however, voluntary and legal actions against the use of legacy PFASs were only implemented in recent years. These actions are aimed to trigger certain trends in PFAS chemistry, leading to the introduction of novel PFASs or the fortified use of short-chain derivativ ...
DOI:
10.1016/j.trac.2019.01.017

9. Oncolipidomics: Mass spectrometric quantitation of lipids in cancer research

Author:
Wolrab, Denise; Jirásko, Robert; Chocholoušková, Michaela; Peterka, Ondřej; Holčapek, Michal
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
body fluids; cell lines; lipids; mass spectrometry; neoplasms; quantitative analysis; tissues
Abstract:
... This review summarizes available mass spectrometry (MS) based approaches for the quantitative analysis of lipids in biological samples in the cancer research, which is termed here as oncolipidomics. The methodological part shows possible configurations of stand-alone MS or MS coupled to liquid-phase separation techniques. For the characterization of various lipids with the special emphasis on meth ...
DOI:
10.1016/j.trac.2019.04.012

10. Single-cell metabolomics by mass spectrometry: Advances, challenges, and future applications

Author:
Ali, Ahmed; Abouleila, Yasmine; Shimizu, Yoshihiro; Hiyama, Eiso; Emara, Samy; Mashaghi, Alireza; Hankemeier, Thomas
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
automation; image analysis; mass spectrometry; metabolism; metabolomics; microfluidic technology
Abstract:
... Cellular heterogeneity is a phenomenon that is often observed but poorly understood. Single-cell metabolomics can provide insights into the phenotypical variations between individual cells. Recent advances in microfluidics, micromanipulation, image analysis, and automation allowed for high-throughput isolation of single cells in a minimally disruptive manner as to not affect the cell metabolism. C ...
DOI:
10.1016/j.trac.2019.02.033

11. TEMPORARY REMOVAL: Vibrational spectroscopy for the pharmaceutical industry: From benchtop to handheld innovative applications

Author:
Clavaud, Riccardo Deidda; Sacré, Pierre-Yves; Coic, Laureen; Avohou, Hermane; Hubert, Philippe; Ziemons, Eric
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
issues and policy; pharmaceutical industry; spectroscopy
Abstract:
... The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
DOI:
10.1016/j.trac.2018.11.045

12. Towards a comprehensive analytical workflow for the chemical characterisation of organofluorine in consumer products and environmental samples

Author:
Koch, Alina; Aro, Rudolf; Wang, Thanh; Yeung, Leo W.Y.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
analytical methods; detection limit; fluorides; products and commodities; reference standards; screening
Abstract:
... This review summarizes and discusses eight analytical methods for organofluorine (OF) analysis, which offer detection limits suitable for consumer products and environmental samples. Direct sample analysis of OF only applies to some techniques on consumer products, whereas others require sample pre-treatment or concentration before measurements. Comparison between methods for OF analysis were foun ...
DOI:
10.1016/j.trac.2019.02.024

13. Tracing metabolic fluxes using mass spectrometry: Stable isotope-resolved metabolomics in health and disease

Author:
Balcells, Cristina; Foguet, Carles; Tarragó-Celada, Josep; de Atauri, Pedro; Marin, Silvia; Cascante, Marta
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
biochemical pathways; isotopes; mass spectrometry; metabolism; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; phenotype; prediction
Abstract:
... Tracing metabolic fluxes, defined as the reaction and transport rates in living cells, is essential to characterize metabolic phenotypes. One of the most informative methods to predict fluxes is stable isotope-resolved metabolomics (SIRM). In SIRM, a biological system is fed with substrates labeled with stable heavy isotopes. This isotopic label propagates along metabolic pathways and is incorpora ...
DOI:
10.1016/j.trac.2018.12.025

14. Unique analytical considerations for laboratory studies identifying metabolic products of per- and polyfluoroalkyl substances (PFASs)

Author:
Joudan, Shira; Liu, Runzeng; D'eon, Jessica C.; Mabury, Scott A.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
animal models; biotransformation; experimental design; gas chromatography-mass spectrometry; high performance liquid chromatography; ion exchange chromatography; laboratory experimentation; metabolism; metabolites; microorganisms; nuclear magnetic resonance spectroscopy; organofluorine compounds
Abstract:
... Laboratory experiments investigating the biotransformation of per- and polyfluoroalkyl substances (PFASs) require unique analytical considerations due to the physicochemical properties of highly fluorinated molecules. Here, we review experiments performed using microbial systems, in vivo animal models or in vitro systems that search for novel transformation products. Researchers have made analytic ...
DOI:
10.1016/j.trac.2019.02.032

15. Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment

Author:
Nakayama, Shoji F.; Yoshikane, Mitsuha; Onoda, Yu; Nishihama, Yukiko; Iwai-Shimada, Miyuki; Takagi, Mai; Kobayashi, Yayoi; Isobe, Tomohiko
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
air; analytical methods; environmental impact; geographical distribution; human health; perfluorocarbons; risk assessment; world markets
Abstract:
... Numerous poly- and perfluoroalkyl substances (PFAS) have been manufactured and distributed on the world market. Research on PFAS has highlighted their global distribution and impacts on ecosystems and human health. Following regulations and public concern, PFAS production has shifted toward novel molecules in recent years. New classes of PFAS have been identified in the environment and are gaining ...
DOI:
10.1016/j.trac.2019.02.011